ArticleFEBS letters2017
Modulation of Wnt signaling is essential for the differentiation of ciliated epithelial cells in human airways.
Article in FEBS letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Elevated COAllergy · 2026Article
- Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies.Journal of cell science · 2025Article
- Single-cell transcriptomics reveals e-cigarette vapor-induced airway epithelial remodeling and injury.Respiratory research · 2024Article
- Extensive airway remodelling in severe COPD imparts resiliency to environmental stressors.Thorax · 2024Article
- Formation and function of multiciliated cells.The Journal of cell biology · 2024Review
- A WNT4- and DKK3-driven canonical to noncanonical Wnt signaling switch controls multiciliogenesis.Journal of cell science · 2023Article
- Single-cell RNA sequencing reveals the developmental program underlying proximal-distal patterning of the human lung at the embryonic stage.Cell research · 2023Article
- Human Airway Basal Cells Undergo Reversible Squamous Differentiation and Reshape Innate Immunity.American journal of respiratory cell and molecular biology · 2023Article
- An essential function for autocrine hedgehog signaling in epithelial proliferation and differentiation in the trachea.Development (Cambridge, England) · 2022Article
- Analysis of pathological changes in the epithelium in COVID-19 patient airways.ERJ open research · 2021Article
- Long noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation state.Physiological reports · 2021Article
- Aquatic models of human ciliary diseases.Genesis (New York, N.Y. : 2000) · 2021Review
- GSK-3 Inhibition Modulates Metalloproteases in a Model of Lung Inflammation and Fibrosis.Frontiers in molecular biosciences · 2021Article
- Hyperglycaemia in cystic fibrosis adversely affects BK channel function critical for mucus clearance.The European respiratory journal · 2021Article
- Losartan reduces cigarette smoke-induced airway inflammation and mucus hypersecretion.ERJ open research · 2021Article
- An Adverse Outcome Pathway for Decreased Lung Function Focusing on Mechanisms of Impaired Mucociliary Clearance Following Inhalation Exposure.Frontiers in toxicology · 2021Article
- Canonical WNT pathway is activated in the airway epithelium in chronic obstructive pulmonary disease.EBioMedicine · 2020Article
- Downregulation of LINC00707 promotes osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells by regulating DKK1 via targeting miR‑103a‑3p.International journal of molecular medicine · 2020Article
- Analysis of ciliogenesis process in the bovine oviduct based on immunohistochemical classification.Molecular biology reports · 2020Article
- Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures.Development (Cambridge, England) · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Wnt signaling is essential for the differentiation of airway epithelial cells during development. Here, we examined the role of Wnt signaling during redifferentiation of ciliated airway epithelial cells in vitro at the air liquid interface as a model of airway epithelial repair. Phases of proliferation and differentiation were defined. Markers of squamous metaplasia and epithelial ciliation were followed while enhancing β-catenin signaling by blocking glycogen synthase kinase 3β with SB216763 and shRNA as well as inhibiting canonical WNT signaling with apical application of Dickkopf 1 (Dkk1). Our findings indicate that enhanced β-catenin signaling decreases the number of ciliated cells and causes squamous changes in the epithelium, whereas treatment with DDk1 leads to an increased number of ciliated cells.
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