ArticleJournal of gastroenterology2018
Basophils activated via TLR signaling may contribute to pathophysiology of type 1 autoimmune pancreatitis.
Article in Journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Autoimmune fibroinflammation in IgG4-related ophthalmic disease: TLR8-dependent signaling pathways and fibrotic remodeling revealed by proteomic profiling.Frontiers in immunology · 2026Article
- Single-cell multi-omics analysis revealed the expansion of age-associated B cells in the pancreas of type 1 autoimmune pancreatitis patients.Genome medicine · 2025Article
- Review
- Oxidative stress, DAMPs, and immune cells in acute pancreatitis: molecular mechanisms and therapeutic prospects.Frontiers in immunology · 2025Review
- IgG4-related disease presenting with hypercalcemia: case report and mechanistic insights.Frontiers in immunology · 2025Article
- Basophils beyond allergic and parasitic diseases.Frontiers in immunology · 2023Review
- Current status of type 1 (IgG4-related) autoimmune pancreatitis.Journal of gastroenterology · 2022Review
- CD163+ M2 Macrophages Promote Fibrosis in IgG4-Related Disease Via Toll-like Receptor 7/Interleukin-1 Receptor-Associated Kinase 4/NF-κB Signaling.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- IgG4-related diseases of the digestive tract.Nature reviews. Gastroenterology & hepatology · 2022Review
- Role of Basophils in a Broad Spectrum of Disorders.Frontiers in immunology · 2022Review
- Gut microbiota alterations and health status in aging adults: From correlation to causation.Aging medicine (Milton (N.S.W)) · 2021Review
- Autoimmune pancreatitis and pancreatic cancer: Epidemiological aspects and immunological considerations.World journal of gastroenterology · 2021Review
- Biomarkers in autoimmune pancreatitis and immunoglobulin G4-related disease.World journal of gastroenterology · 2021Article
- The Cellular and Molecular Bases of Allergy, Inflammation and Tissue Fibrosis in Patients with IgG4-related Disease.International journal of molecular sciences · 2020Review
- Chronic Pancreatitis and the Development of Pancreatic Cancer.Endocrine, metabolic & immune disorders drug targets · 2020Review
- Immunological mechanism of IgG4-related disease.Journal of translational autoimmunity · 2020Article
- Activated M2 Macrophages Contribute to the Pathogenesis of IgG4-Related Disease via Toll-like Receptor 7/Interleukin-33 Signaling.Arthritis & rheumatology (Hoboken, N.J.) · 2020Article
- Immunoglobulin G4-related Disease: An Overview.JMA journal · 2019Review
- Response to the Letter by Poddighe et al. regarding our manuscript "Basophils activated via TLR signaling may contribute to pathophysiology of type 1 autoimmune pancreatitis".Journal of gastroenterology · 2018Article
- Basophils activated via TLR signaling may contribute to pathophysiology of type I autoimmune pancreatitis".Journal of gastroenterology · 2018Article
Corrections and comments
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- Erratum issued
Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPathophysiology of type 1 autoimmune pancreatitis (AIP) is still unclear. We previously reported that M2 macrophages might play an important role in type 1 AIP. Recently, it has been reported that basophils regulate differentiation to M2 macrophages. In this study, we investigated basophils from the pancreatic tissue and peripheral blood of individuals with type 1 AIP.
methodsBy using immunohistochemistry, we investigated basophils in pancreatic tissue from 13 patients with type 1 AIP and examined expression of toll-like receptors (TLRs) by these cells. Additionally, we obtained peripheral blood samples from 27 healthy subjects, 40 patients with type 1 AIP, 8 patients with alcoholic chronic pancreatitis, 10 patients with bronchial asthma, and 10 patients with atopic dermatitis, and analyzed activation of basophils by stimulating them with ligands of TLR1-9. We also compared TLR expression in basophils from the tissue and blood samples.
resultsBasophils were detected in pancreatic tissues from 10 of 13 patients with type 1 AIP. Flow cytometric analysis revealed that the ratios of basophils activated by TLR4 stimulation in type 1 AIP (9.875 ± 1.148%) and atopic dermatitis (11.768 ± 1.899%) were significantly higher than those in healthy subjects (5.051 ± 0.730%; P < 0.05). Levels of basophils activated by TLR2 stimulation were higher in seven type 1 AIP cases. Furthermore, stimulation of TLR2 and/or TLR4, which were expressed by basophils in pancreas, activated basophils in peripheral blood.
conclusionsBasophils activated via TLR signaling may play an important role in the pathophysiology of type 1 AIP.
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