Evidence map›Paper›PMID 28921163›Full record

ArticlePsychopharmacology2017

Discriminative stimulus properties of the atypical antipsychotic amisulpride: comparison to its isomers and to other benzamide derivatives, antipsychotic, antidepressant, and antianxiety drugs in C57BL/6 mice.

Timothy J Donahue, Todd M Hillhouse, Kevin A Webster, Richard Young, Eliseu O De Oliveira, Joseph H Porter

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Timothy J DonahueDepartment of Psychology, Virginia Commonwealth University, 806 West Franklin Street, PO Box 842018, Richmond, VA, 23284-2018, USA.
Todd M HillhouseDepartment of Psychology, Weber State University, Ogden, UT, USA.
Kevin A WebsterDepartment of Psychology, Virginia Commonwealth University, 806 West Franklin Street, PO Box 842018, Richmond, VA, 23284-2018, USA.
Richard YoungDepartment of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA, USA.
Eliseu O De OliveiraDepartment of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, USA.
Joseph H PorterDepartment of Psychology, Virginia Commonwealth University, 806 West Franklin Street, PO Box 842018, Richmond, VA, 23284-2018, USA. jporter@vcu.edu.
Virginia Commonwealth University · USWeber State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleRacemic (RS)-amisulpride (Solian

objectivesThe present study established (RS)-amisulpride as a discriminative stimulus and assessed amisulpride-like effects of amisulpride stereoisomers, other benzamide derivatives, and antipsychotic, antidepressant, and anxiolytic drugs.

methodsAdult, male C57BL/6 mice were trained to discriminate 10 mg/kg (RS)-amisulpride from vehicle in a two-lever food-reinforced operant conditioning task.

results(RS)-Amisulpride's discriminative stimulus was dose-related, time-dependent, and stereoselective. (S)-Amisulpride (an effective dose of 50% (ED

conclusions(RS)-Amisulpride generalized to some, but not all benzamide derivatives, and it failed to generalize to any other antipsychotic, antidepressant, or antianxiety drugs tested. Interestingly, the (R)-isomer shared very strong stimulus properties with (RS)-amisulpride. This finding was in contrast to findings from Donahue et al. (Eur J Pharmacol 734:15-22, 2014), which found that the (R)-isomer did not share very strong stimulus properties when the (S)-isomer was the training drug.

Indexed as

AmisulprideAnimalsAnti-Anxiety AgentsAntidepressive AgentsAntipsychotic AgentsBenzamidesChlorpromazineClozapineConditioning, OperantDiscrimination LearningMaleMiceMice, Inbred C57BLQuetiapine FumarateRisperidoneSulpirideAmisulprideAnti-Anxiety AgentsAntidepressive AgentsAntipsychotic AgentsBenzamidesChlorpromazineClozapineQuetiapine FumarateRisperidoneSulpirideAmisulprideAntidepressantsAntipsychoticsAnxiolyticsBenzamidesC57BL/6 miceDiscriminative stimulusDrug discriminationIsomersSchizophrenia

Identifiers

PMID28921163
OpenAlexW2755377761

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.