Evidence map›Paper›PMID 28920931›Full record

ArticleNature chemical biology2017

Single-molecule FRET reveals the energy landscape of the full-length SAM-I riboswitch.

Christoph Manz, Andrei Yu Kobitski, Ayan Samanta, Bettina G Keller, Andres Jäschke, G Ulrich Nienhaus

Abstract read
PubMed Publisher
In one paragraph

Article in Nature chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Article
  3. Bayesian Nonparametrics for FRET using Realistic Integrative Detectors.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. FRET-guided modeling of nucleic acids.Nucleic acids research · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Strategies for Covalent Labeling of Long RNAs.Chembiochem : a European journal of chemical biology · 2021
    Review
  17. Article
  18. Article
  19. Tag-Free Internal RNA Labeling and Photocaging Based on mRNA Methyltransferases.Angewandte Chemie (International ed. in English) · 2021
    Article
  20. Covalent labeling of nucleic acids.Chemical Society reviews · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Christoph ManzInstitute of Applied Physics, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Andrei Yu KobitskiInstitute of Applied Physics, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Ayan SamantaInstitute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, Heidelberg, Germany.
Bettina G KellerFreie Universität Berlin, Institute of Chemistry and Biochemistry, Berlin, Germany.
Andres JäschkeHeidelberg Karlsruhe Research Partnership (HEiKA), Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.
G Ulrich NienhausInstitute of Applied Physics, Karlsruhe Institute of Technology, Karlsruhe, Germany.ORCID http://orcid.org/0000-0002-5027-3192
Karlsruhe Institute of Technology · DEFreie Universität Berlin · DEHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

S-adenosyl-L-methionine (SAM) ligand binding induces major structural changes in SAM-I riboswitches, through which gene expression is regulated via transcription termination. Little is known about the conformations and motions governing the function of the full-length Bacillus subtilis yitJ SAM-I riboswitch. Therefore, we have explored its conformational energy landscape as a function of Mg

Indexed as

Nucleic Acid ConformationRiboswitchBacillus subtilisFluorescence Resonance Energy TransferLigandsMagnesiumModels, MolecularRNA, BacterialS-AdenosylmethionineLigandsMagnesiumRiboswitchRNA, BacterialS-Adenosylmethionine

Identifiers

PMID28920931
OpenAlexW2754851234

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.