Evidence map›Paper›PMID 28920762›Full record

ArticleTranscription2018

Measuring dynamics of eukaryotic transcription initiation: Challenges, insights and opportunities.

Zhengjian Zhang, Robert Tjian

Abstract read
In one paragraph

Article in Transcription, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Transcriptional Regulation and Implications for ControllingJournal of developmental biology · 2022
    Review
  5. Journal of biosciences · 2022
    Review
  6. Review
  7. Dynamics of RNA polymerase II and elongation factor Spt4/5 recruitment during activator-dependent transcription.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zhengjian Zhanga Surrozen Incorporation , South San Francisco , CA , USA.
Robert Tjianb Howard Hughes Medical Institute, Li Ka Shing Center for Biomedical and Health Sciences and Department of Molecular and Cell Biology, University of California , Berkeley , CA , USA.ORCID 0000-0003-0539-8217

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Transcription of protein-encoding genes in eukaryotic cells is a dynamically coordinated process. Many of the key transcription regulators contain functionally essential intrinsically disordered regions (IDRs), the dynamic nature of which creates extra challenges to traditional biochemical analyses. Recent advances in single-molecule fluorescence imaging technology have enabled direct visualization of these rapid, complex and dynamic molecular interactions in real time.

Indexed as

Transcription Initiation, GeneticAnimalsHumansIntrinsically Disordered ProteinsOptical ImagingPromoter Regions, GeneticTranscription Factors, GeneralTranscription Factor TFIIDIntrinsically Disordered ProteinsTranscription Factors, GeneralTranscription Factor TFIIDdynamic analysisfluorescence imagingintrinsically disordered regionspreinitiation complexsingle-moleculetranscription

Identifiers

PMID28920762
PMCPMC5927711

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.