ArticleTissue engineering. Part A2018
Functional Mechanics of a Pectin-Based Pleural Sealant after Lung Injury.
Article in Tissue engineering. Part A, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Plant heteropolysaccharides and their bioadhesion to animal glycocalyx visualized at the nanoscale.Communications biology · 2026Article
- Biomechanics of a Plant-Derived Sealant for Corneal Injuries.Translational vision science & technology · 2023Article
- 3D stimulated Raman spectral imaging of water dynamics associated with pectin-glycocalyceal entanglement.Biomedical optics express · 2023Article
- Article
- Kinetics of Pectin Biopolymer Facial Erosion Characterized by Fluorescent Tracer Microfluidics.Polymers · 2022Article
- Article
- Steam Explosion (STEX) ofBiology · 2021Article
- Article
- Development of alginate and gelatin-based pleural and tracheal sealants.Acta biomaterialia · 2021Article
- Analysis and Potential Value of Compounds Extracted From Star Ruby, Rio Red, and Ruby Red Grapefruit, and Grapefruit Juice Processing ResiduesFrontiers in nutrition · 2021Article
- Seeking Answers from Tradition: Facile Preparation of Durable Adhesive Hydrogel Using Natural Quercetin.iScience · 2020Article
- An organosynthetic soft robotic respiratory simulator.APL bioengineering · 2020Article
- Pectin biopolymer mechanics and microstructure associated with polysaccharide phase transitions.Journal of biomedical materials research. Part A · 2020Article
- Plant-inspired adhesive and tough hydrogel based on Ag-Lignin nanoparticles-triggered dynamic redox catechol chemistry.Nature communications · 2019Article
- Structural heteropolysaccharides as air-tight sealants of the human pleura.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Pleural injury and associated air leaks are a major influence on patient morbidity and healthcare costs after lung surgery. Pectin, a plant-derived heteropolysaccharide, has recently demonstrated potential as an adhesive binding to the glycocalyx of visceral mesothelium. Since bioadhesion is a process likely involving the interpenetration of the pectin-based polymer with the glycocalyx, we predicted that the pectin-based polymer may also be an effective sealant for pleural injury. To explore the potential role of an equal (weight%) mixture of high-methoxyl pectin and carboxymethylcellulose as a pleural sealant, we compared the yield strength of the pectin-based polymer to commonly available surgical products. The pectin-based polymer demonstrated significantly greater adhesion to the lung pleura than the comparison products (p < 0.001). In a 25 g needle-induced lung injury model, pleural injury resulted in an air leak and a loss of airway pressures. After application of the pectin-based polymer, there was a restoration of airway pressure and no measurable air leak. Despite the application of large sheets (50 mm
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