Evidence map›Paper›PMID 28920557›Full record

ArticleThyroid : official journal of the American Thyroid Association2017

Automated MicroSPECT/MicroCT Image Analysis of the Mouse Thyroid Gland.

Peng Cheng, Brynn Hollingsworth, Daniel Scarberry, Daniel H Shen, Kimerly Powell, Sean C Smart, John Beech, Xiaochao Sheng, Lawrence S Kirschner, Chia-Hsiang Menq and 1 more

Open access · greenAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Thyroid : official journal of the American Thyroid Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Peng Cheng1 Department of Mechanical and Aerospace Engineering, The Ohio State University , Columbus, Ohio.
Brynn Hollingsworth2 Department of Physiology and Cell Biology, The Ohio State University , Columbus, Ohio.
Daniel Scarberry2 Department of Physiology and Cell Biology, The Ohio State University , Columbus, Ohio.
Daniel H Shen3 PET Center and Department of Nuclear Medicine, Tri-Service General Hospital, National Defense Medical Center , Taipei, Taiwan .
Kimerly Powell4 Department of Biomedical Informatics, The Ohio State University , Columbus, Ohio.
Sean C Smart5 Department of Oncology, University of Oxford , Oxford, United Kingdom .
John Beech5 Department of Oncology, University of Oxford , Oxford, United Kingdom .
Xiaochao Sheng1 Department of Mechanical and Aerospace Engineering, The Ohio State University , Columbus, Ohio.
Lawrence S Kirschner6 Department of Internal Medicine, The Ohio State University , Columbus, Ohio.
Chia-Hsiang Menq1 Department of Mechanical and Aerospace Engineering, The Ohio State University , Columbus, Ohio.
Sissy M Jhiang2 Department of Physiology and Cell Biology, The Ohio State University , Columbus, Ohio.
The Ohio State University · USUniversity of Oxford · GBTri-Service General Hospital · TW

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Selective Modulation of Thyroidal RadioiodineP01CA124570 · NCI · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2008 to 2017
$23.4M
The Ohio State University and MD Anderson Cancer Center Thyroid Cancer SPOREP50CA168505 · NCI · OHIO STATE UNIVERSITY · PI DE LA CHAPELLE, ALBERT · 2013 to 2017
$10.9M
Comprehensive Training in Oral &Craniofacial SciencesT32DE014320 · NIDCR · OHIO STATE UNIVERSITY · PI SHERIDAN, JOHN F · 2001 to 2022
$10.2M
Cancer Research UK 16466NCI NIH HHS P01 CA124570NCI NIH HHS P30 CA016058NCI NIH HHS P50 CA168505NIDCR NIH HHS T32 DE014320
6 · The paper itself

Abstract

backgroundThe ability of thyroid follicular cells to take up iodine enables the use of radioactive iodine (RAI) for imaging and targeted killing of RAI-avid thyroid cancer following thyroidectomy. To facilitate identifying novel strategies to improve

methodsA customized mouse cradle was designed and used for microSPECT/CT image acquisition at 1 hour (t1) and 24 hours (t24) post injection of

resultsThe customized mouse cradle facilitates consistent tissue configuration among image acquisitions such that rigid body registration can be applied to align serial images of the same mouse via the in-house CTViewer software. CTViewer is designed specifically to streamline SPECT/CT image analysis with functions tailored to quantify thyroid radioiodine uptake. Automatic segmentation of thyroid volumes of interest (VOI) from adjacent salivary glands in t1 images is enabled by superimposing the thyroid VOI from the t24 image onto the corresponding aligned t1 image. The extent of heterogeneity in

conclusionsMicroSPECT/CT image acquisition and analysis for thyroidal RAI uptake is greatly improved by the cradle and the CTViewer software, respectively. Furthermore, the approach of superimposing thyroid VOIs from t24 images to select thyroid VOIs on corresponding aligned t1 images can be applied to studies in which the target tissue has differential radiotracer retention from surrounding tissues.

Indexed as

X-Ray MicrotomographyAnimalsAutomationEquipment DesignInjections, IntravenousIodine RadioisotopesMice, TransgenicMutationPredictive Value of TestsProto-Oncogene Proteins B-rafRadiographic Image Interpretation, Computer-AssistedRadiopharmaceuticalsReproducibility of ResultsRestraint, PhysicalSingle Photon Emission Computed Tomography Computed TomographySoftwareBRAF protein, humanIodine RadioisotopesProto-Oncogene Proteins B-rafRadiopharmaceuticalscradleCTmouseradioiodineSPECTthyroid

Identifiers

PMID28920557
PMCPMC5672640
OpenAlexW2754695468

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.