ArticleAsian-Australasian journal of animal sciences2018
Effects of aflatoxin B1 combined with ochratoxin A and/or zearalenone on metabolism, immune function, and antioxidant status in lactating dairy goats.
Article in Asian-Australasian journal of animal sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Mycotoxin contamination in food and feed: Occurrence, co-occurrence, combined impacts on human and animal health, climate change implications, risk assessment, and mitigation strategies.Mycotoxin research · 2026Review
- Mycotoxins Co-Exposure Risk Assessment in Coix Seed: Contamination Levels and Safety for Dietary Consumption and Medicinal Intake.Foods (Basel, Switzerland) · 2025Article
- Combination of Anti-Mycotoxin Additive in Diet Contaminated with Multiple Mycotoxins (Aflatoxin, Fumonisin, Zearalenone and Deoxynivalenol): Effects on Performance and Health of Lambs.Animals : an open access journal from MDPI · 2025Article
- Multiple Mycotoxin Contamination in Livestock Feed: Implications for Animal Health, Productivity, and Food Safety.Toxins · 2025Review
- Deepening the Modulatory Activity of Bioactive Compounds Against AFB1- and OTA-Induced Neuronal Toxicity Through a Proteomic Approach.Antioxidants (Basel, Switzerland) · 2025Article
- Effect of oral administration ofOpen veterinary journal · 2025Article
- Mycotoxin concentrations in rice are affected by chalkiness, grain shape, processing type, and grain origin.Mycotoxin research · 2025Article
- Duration of Zearalenone Exposure Has Implications on Health Parameters of Lactating Cows.Toxins · 2024Article
- The Effects of Aflatoxin B1 Intake in Assaf Dairy Ewes on Aflatoxin M1 Excretion, Milk Yield, Haematology and Biochemical Profile.Animals : an open access journal from MDPI · 2023Article
- Nutritional impact of mycotoxins in food animal production and strategies for mitigation.Journal of animal science and biotechnology · 2022Review
- Article
- Effects of embryo injected with ochratoxins A on hatching quality and jejunum antioxidant capacity of ducks at hatching.Frontiers in veterinary science · 2022Article
- An Immunoenzymatic Method for the Determination of Ochratoxin A in Biological Liquids (Colostrum and Cow's Milk).Toxins · 2021Article
- Aflatoxins: History, Significant Milestones, Recent Data on Their Toxicity and Ways to Mitigation.Toxins · 2021Review
- Aflatoxin in Dairy Cows: Toxicity, Occurrence in Feedstuffs and Milk and Dietary Mitigation Strategies.Toxins · 2021Review
- Impact of Mycotoxins on Animals' Oxidative Status.Antioxidants (Basel, Switzerland) · 2021Review
- Evaluation of the Multimycotoxin-Degrading Efficiency ofInternational journal of molecular sciences · 2021Article
- Article
- The biochemical and metabolic profiles of dairy cows with mycotoxins-contaminated diets.PeerJ · 2020Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis experiment investigated the effects of aflatoxin B1 (AFB1) alone or mixed with ochratoxin A (OTA) and/or zearalenone (ZEA) on the metabolism, immune function, and antioxidant status of dairy goats.
methodsFifty lactating Laoshan dairy goats were randomly assigned to one of five treatment groups (n = 10) for 14 days. Goats were fed no additive (control) or administered with 50 μg AFB1/kg dry matter (DM) (AFB1), 50 μg AFB1/kg DM+100 μg OTA/kg DM (AFB1+ OTA), 50 μg AFB1/kg DM+500 μg ZEA/kg DM (AFB1+ZEA), or 50 μg AFB1/kg DM+100 μg OTA/kg DM+500 μg ZEA/kg DM (AFB1+OTA+ZEA).
resultsDry matter intake and milk production were lower in goats fed AFB1+OTA+ZEA than in controls. Supplementation with AFB1, OTA, and ZEA significantly decreased red blood cell count, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, and mean platelet volume, and significantly increased white blood cell count, when compared with the control group. Compared with control, the combination of AFB1, OTA, and ZEA significantly increased alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities, total bilirubin (TBIL), interleukin-6, and malondialdehyde (MDA), but significantly reduced immunoglobulin A concentration, the activities of superoxide dismutase (SOD) and glutathione peroxides (GSH-Px), and total antioxidant capacity (T-AOC) in serum. Administration of AFB1 combined with OTA led to higher ALP, ALT, TBIL, and MDA, as well as lower milk production, SOD and GSH-Px activities, and T-AOC, than administration of AFB1 combined with ZEA.
conclusionThe mixture of AFB1, OTA, and ZEA exerted the greatest adverse effects on dairy goats, meanwhile the deleterious damage of the other mycotoxin combinations were in varying degrees. The findings of this study could provide guidance for the prevention and treatment of the consequences of contamination of animal feeds with combinations of mycotoxin.
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