ReviewBurns & trauma2017
The influence of sex steroid hormones on the response to trauma and burn injury.
Review in Burns & trauma, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase IIa Clinical Trial to Evaluate Pharmacokinetics and Safety of Slow Release DHEA
A Study to Evaluate Efficacy and Safety of Slow Release DHEA
Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Hallmarks of the multidimensional immune response to trauma in humans.Nature immunology · 2026Review
- Endocrine disruptions in thermal injuries: exploring immune system interactions.Physiological reviews · 2026Review
- Cellular and molecular changes in the skin driving increased nociception and pain during burn injury and repair.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Estrogen Treatment Lowers the Risk of Complications in Menopausal Women with Mild Burn Injury.Medicina (Kaunas, Lithuania) · 2025Article
- Research progress on the role of fascia in skin wound healing.Burns & trauma · 2025Review
- Prediction of malignant esophageal fistula in esophageal cancer using a radiomics-clinical nomogram.European journal of medical research · 2024Article
- Sex-Related Mortality After Burns: A Scoping Review in the Sadc-Region.Annals of burns and fire disasters · 2023Article
- Prevalence and Management Outcomes of Burns in a Teaching Hospital in Ekiti State, Nigeria: A Five-Year Review.Annals of burns and fire disasters · 2022Review
- The Association of Gender and Mortality in Geriatric Trauma Patients.Healthcare (Basel, Switzerland) · 2022Review
- Beyond the Trauma Triad of Death-New Advances in Our Knowledge of Pathophysiology as a Basis for New Perspectives in Support Therapy.Life (Basel, Switzerland) · 2022Article
- Integration of Metabolomic and Clinical Data Improves the Prediction of Intensive Care Unit Length of Stay Following Major Traumatic Injury.Metabolites · 2021Article
- Fast and Sensitive Screening of Oxandrolone and Its Major Metabolite 17-Epi-Oxandrolone in Human Urine by UHPLC-MS/MS with On-Line SPE Sample Pretreatment.Molecules (Basel, Switzerland) · 2021Article
- Resuscitative endovascular balloon occlusion of the aorta (REBOA) in a swine model of hemorrhagic shock and blunt thoracic injury.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Article
- Survival and prognostic factors of patients with esophageal fistula in advanced esophageal squamous cell carcinoma.Bioscience reports · 2020Article
- 17β-Estradiol, a potential ally to alleviate SARS-CoV-2 infection.Clinics (Sao Paulo, Brazil) · 2020Review
- Possible protective role of 17β-estradiol against COVID-19.Journal of allergy and infectious diseases · 2020Article
- Acute primary testicular failure due to radiotherapy increases risk of severe postoperative adverse events in rectal cancer patients.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2020Article
- Sex-Based Differences in Inpatient Burn Mortality.World journal of surgery · 2019Article
- Understanding acute burn injury as a chronic disease.Burns & trauma · 2019Review
- Dehydroepiandrosterone: a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient.Burns & trauma · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Trauma and related sequelae result in disturbance of homeostatic mechanisms frequently leading to cellular dysfunction and ultimately organ and system failure. Regardless of the type and severity of injury, gender dimorphism in outcomes following trauma have been reported, with females having lower mortality than males, suggesting that sex steroid hormones (SSH) play an important role in the response of body systems to trauma. In addition, several clinical and experimental studies have demonstrated the effects of SSH on the clinical course and outcomes following injury. Animal studies have reported the ability of SSH to modulate immune, inflammatory, metabolic and organ responses following traumatic injury. This indicates that homeostatic mechanisms, via direct and indirect pathways, can be maintained by SSH at local and systemic levels and hence result in more favourable prognosis. Here, we discuss the role and mechanisms by which SSH modulates the response of the body to injury by maintaining various processes and organ functions. Such properties of sex hormones represent potential novel therapeutic strategies and further our understanding of current therapies used following injury such as oxandrolone in burn-injured patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.