ReviewAnesthesiology and pain medicine2017
Parasympathetic Cholinergic and Neuropeptide Mechanisms of Migraine.
Review in Anesthesiology and pain medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Association Between Asthma and Migraine: A Systematic Review and Meta-Analysis of Observational Studies.Frontiers in allergy · 2021Pooled it
- Antinociceptive Effects of Exogenous and Endogenous Carbon Monoxide in the Nitroglycerin-Induced Migraine Model in Rats.International journal of molecular sciences · 2026Article
- Peripheral Parasympathetic Networks in Pain: A Systems-Level Review of Mechanisms and Modulations.Cellular and molecular neurobiology · 2025Review
- Stable intracranial imaging of dura mater-engrafted pancreatic islet cells in awake mice.Nature communications · 2025Article
- Hallmarks of primary headache: part 3 - cluster headache.The journal of headache and pain · 2025Review
- The Role of Purinergic Mechanisms in the Excitability of Trigeminal Afferents of Rats with Prenatal Hyperhomocysteinemia.Biomolecules · 2025Article
- Anatomical and physiological contributions of nasal turbinate vessels and lymphatics to the pathogenesis of nasal congestion in recurrent headaches: a pilot study.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Impact of migraine on changes in cardiovascular health profile among Hong Kong Chinese women: insights from the MECH-HK cohort study.The journal of headache and pain · 2024Article
- Assessing the association between age at first sexual intercourse and migraine: a Mendelian randomization study.Frontiers in neurology · 2024Article
- Mechanotransduction: Exploring New Therapeutic Avenues in Central Nervous System Pathology.Frontiers in neuroscience · 2022Review
- Article
- Does Cholinergic Stimulation Affect the P2X7 Receptor-Mediated Dye Uptake in Mast Cells and Macrophages?Frontiers in cellular neuroscience · 2020Article
- Bidirectional association between asthma and migraines in adults: Two longitudinal follow-up studies.Scientific reports · 2019Article
- Update on the pathophysiology of cluster headache: imaging and neuropeptide studies.Journal of pain research · 2019Review
- Shared Fate of Meningeal Mast Cells and Sensory Neurons in Migraine.Frontiers in cellular neuroscience · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextMigraine mechanisms remain largely uncovered for various reasons including a very high complexity of the neurophysiological mechanisms implicated in this disorder and a plethora of endogenous biologically active compounds involved in the pathological process. The functional role of parasympathetic innervation of meninges and cholinergic mechanisms of migraine are among little explored issues despite multiple evidence indirectly indicating the role of acetylcholine (ACh) and its analogues in migraine and other types of headache. In the current short review, we discuss morphological, functional, and clinical issues related to the role of ACh and its analogues such as carbachol and nicotine in this most common neurological disorder. EVIDENCE ACQUISITION: In the present work, studies published from 1953 to 2016 were investigated. Literature was searched with following keywords: acetylcholine (ACh), carbachol, nicotine, parasympathetic, mast cells, vasoactive intestinal polypeptide (VIP), and pituitary adenylate cyclase-activating polypeptide (PACAP).
resultsParasympathetic fibers originated from SPG and trigeminal nerves can interact at the level of meninges which is considered to be the origin site of migraine pain. Here, in dura mater, ACh, VIP, and PACAP released by parasympathetic afferents can both affect mast cells provoking its degranulation and additional release of neurotransmitters, or they can directly affect trigeminal nerves inducing nociception.
conclusionsIn summary, cholinergic mechanisms in migraine and other types of headache remain little elucidated and future studies should clarify the role of parasympathetic nerves and molecular mechanisms of cholinergic modulation within the nociceptive system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.