Evidence map›Paper›PMID 28919998›Full record

ArticleOncoimmunology

Reciprocal influence of B cells and tumor macro and microenvironments in the

Francesca Mion, Stefania Vetrano, Silvia Tonon, Viviana Valeri, Andrea Piontini, Alessia Burocchi, Luciana Petti, Barbara Frossi, Alessandro Gulino, Claudio Tripodo and 2 more

Abstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Francesca MionDepartment of Medicine, University of Udine, Udine, Italy.
Stefania VetranoInflammatory Bowel Disease Center, Humanitas Research Hospital, Rozzano, Italy.
Silvia TononDepartment of Medicine, University of Udine, Udine, Italy.
Viviana ValeriDepartment of Medicine, University of Udine, Udine, Italy.
Andrea PiontiniDepartment of Biomedical Sciences, Humanitas University, Milano, Italy.
Alessia BurocchiDepartment of Experimental Oncology and Molecular Medicine, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy.
Luciana PettiDepartment of Biotechnology and Translational Medicine, University of Milan, Milano, Italy.
Barbara FrossiDepartment of Medicine, University of Udine, Udine, Italy.
Alessandro GulinoDepartment of Health Science, Tumor Immunology Unit, Human Pathology Section, Palermo University School of Medicine, Palermo, Italy.
Claudio TripodoDepartment of Health Science, Tumor Immunology Unit, Human Pathology Section, Palermo University School of Medicine, Palermo, Italy.
Mario P ColomboDepartment of Experimental Oncology and Molecular Medicine, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy.
Carlo E PucilloDepartment of Medicine, University of Udine, Udine, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the most fascinating aspects of the immune system is its dynamism, meant as the ability to change and readapt according to the organism needs. Following an insult, we assist to the spontaneous organization of different immune cells which cooperate, locally and at distance, to build up an appropriate response. Throughout tumor progression, adaptations within the systemic tumor environment, or macroenvironment, result in the promotion of tumor growth, tumor invasion and metastasis to distal organs, but also to dramatic changes in the activity and composition of the immune system. In this work, we show the changes of the B-cell arm of the immune system following tumor progression in the

Indexed as

ApcMin/+ miceB lymphocytesIgAIL-10intestinal cancer

Identifiers

PMID28919998
PMCPMC5593718

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.