Evidence map›Paper›PMID 28919986›Full record

ReviewOncoimmunology

Immune biomarkers for prognosis and prediction of responses to immune checkpoint blockade in cutaneous melanoma.

Nicolas Jacquelot, Jonathan M Pitt, David P Enot, Maria Paula Roberti, Connie P M Duong, Sylvie Rusakiewicz, Alexander M Eggermont, Laurence Zitvogel

Abstract readReview
In one paragraph

Review in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
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  10. Review
  11. C-reactive protein as an early marker of immune-related adverse events.Journal of cancer research and clinical oncology · 2019
    Article
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicolas JacquelotGustave Roussy, Université Paris-Saclay, INSERM U1015, Villejuif, F-94805, France.
Jonathan M PittGustave Roussy, Université Paris-Saclay, INSERM U1015, Villejuif, F-94805, France.
David P EnotGustave Roussy, Université Paris-saclay, Metabolomics and Cell Biology Platforms, Villejuif, F-94805, France.
Maria Paula RobertiGustave Roussy, Université Paris-Saclay, INSERM U1015, Villejuif, F-94805, France.
Connie P M DuongGustave Roussy, Université Paris-Saclay, INSERM U1015, Villejuif, F-94805, France.
Sylvie RusakiewiczGustave Roussy, Université Paris-Saclay, INSERM U1015, Villejuif, F-94805, France.
Alexander M EggermontGustave Roussy, Université Paris-saclay, Villejuif, F-94805, France.
Laurence ZitvogelGustave Roussy, Université Paris-Saclay, INSERM U1015, Villejuif, F-94805, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Existing clinical, anatomopathological and molecular biomarkers fail to reliably predict the prognosis of cutaneous melanoma. Biomarkers for determining which patients receive adjuvant therapies are needed. The emergence of new technologies and the discovery of new immune populations with different prognostic values allow the immune network in the tumor to be better understood. Importantly, new molecules identified and expressed by immune cells have been shown to reduce the antitumor immune efficacy of therapies, prompting researchers to develop antibodies targeting these so-called "immune checkpoints", which have now entered the oncotherapeutic armamentarium.

Indexed as

Immune biomarkersImmunotherapyMelanomaPredictive factorsPrognostic factors

Identifiers

PMID28919986
PMCPMC5593705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.