Evidence map›Paper›PMID 28919974›Full record

ArticleBMC biophysics2017

Kinetic and thermodynamic studies reveal chemokine homologues CC11 and CC24 with an almost identical tertiary structure have different folding pathways.

Baosheng Ge, Xiaoyong Jiang, Yao Chen, Tingting Sun, Qiuxia Yang, Fang Huang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biophysics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Baosheng Ge *Center for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao, 266580 People's Republic of China.
Xiaoyong Jiang *Center for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao, 266580 People's Republic of China.
Yao ChenCenter for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao, 266580 People's Republic of China.
Tingting SunCenter for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao, 266580 People's Republic of China.
Qiuxia YangCenter for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao, 266580 People's Republic of China.
Fang HuangCenter for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao, 266580 People's Republic of China.ORCID 0000-0001-8735-0350
China University of Petroleum, East China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProteins with low sequence identity but almost identical tertiary structure and function have been valuable to uncover the relationship between sequence, tertiary structure, folding mechanism and functions. Two homologous chemokines, CCL11 and CCL24, with low sequence identity but similar tertiary structure and function, provide an excellent model system for respective studies.

resultsThe kinetics and thermodynamics of the two homologous chemokines were systematically characterized. Despite their similar tertiary structures, CCL11 and CCL24 show different thermodynamic stability in guanidine hydrochloride titration, with D

conclusionOur results suggest homologous proteins with low sequence identity can display almost identical tertiary structure, but very different folding mechanisms, which applies to homologues in the chemokine protein family, extending the general applicability of the above observation.

Indexed as

ChemokineFolding intermediateHomologous proteinKineticsThermodynamics

Identifiers

PMID28919974
PMCPMC5596964
OpenAlexW2754376740

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.