ArticleJournal of biological engineering2017
In-vitro evaluation of Polylactic acid (PLA) manufactured by fused deposition modeling.
Article in Journal of biological engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 90 citations in OpenAlex.
- Mechanical Performance of FDM-Printed PLA Joined by Portable Friction Stir Welding: Influence of Infill Density and Tool Pin Geometry.Polymers · 2026Article
- Microstructure and Mechanical Performance of 3D-Printed Carbon Fibre-PLA-PHA Composites.Polymers · 2026Article
- L1 vertebral body replacement using 3D-printed polylactic acid bioimplants:Journal of spine surgery (Hong Kong) · 2025Article
- Controlling Mechanical Properties of Medical-Grade Scaffolds through Electrospinning Parameter Selection.ACS omega · 2024Article
- The Mechanical Properties of 3D-Printed Polylactic Acid/Polyethylene Terephthalate Glycol Multi-Material Structures Manufactured by Material Extrusion.3D printing and additive manufacturing · 2024Article
- In Vitro Studies on 3D-Printed PLA/HA/GNP Structures for Bone Tissue Regeneration.Biomimetics (Basel, Switzerland) · 2024Article
- Effect of Sterilization on the Dimensional and Mechanical Behavior of Polylactic Acid Pieces Produced by Fused Deposition Modeling.Polymers · 2023Article
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- Design considerations of benchtop fluid flow bioreactors for bio-engineered tissue equivalentsBiomaterials and biosystems · 2022Article
- The healing of bone defects by cell-free and stem cell-seeded 3D-printed PLA tissue-engineered scaffolds.Journal of orthopaedic surgery and research · 2022Article
- CuJournal of functional biomaterials · 2022Article
- A Comprehensive Review of Biopolymer Fabrication in Additive Manufacturing Processing for 3D-Tissue-Engineering Scaffolds.Polymers · 2022Review
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- Multi-Dimensional Printing for Bone Tissue Engineering.Advanced healthcare materials · 2021Review
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- Modeling the Mechanobiology of Cancer Cell Migration Using 3D Biomimetic Hydrogels.Gels (Basel, Switzerland) · 2021Review
- Article
- Study of Microchannels Fabricated Using Desktop Fused Deposition Modeling Systems.Micromachines · 2020Article
- FDM 3D Printed Composites for Bone Tissue Engineering Based on Plasticized Poly(3-hydroxybutyrate)/poly(d,l-lactide) Blends.Polymers · 2020Article
- Addressing present pitfalls in 3D printing for tissue engineering to enhance future potential.APL bioengineering · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith additive manufacturing (AM) individual and biocompatible implants can be generated by using suitable materials. The aim of this study was to investigate the biological effects of polylactic acid (PLA) manufactured by Fused Deposition Modeling (FDM) on osteoblasts in vitro according to European Norm / International Organization for Standardization 10,993-5.
methodHuman osteoblasts (hFOB 1.19) were seeded onto PLA samples produced by FDM and investigated for cell viability by fluorescence staining after 24 h. Cell proliferation was measured after 1, 3, 7 and 10 days by cell-counting and cell morphology was evaluated by scanning electron microscopy. For control, we used titanium samples and polystyrene (PS).
resultsCell viability showed higher viability on PLA (95,3% ± 2.1%) than in control (91,7% ±2,7%). Cell proliferation was highest in the control group (polystyrene) and higher on PLA samples compared to the titanium samples. Scanning electron microscopy revealed homogenous covering of sample surface with regularly spread cells on PLA as well as on titanium.
conclusionThe manufacturing of PLA discs from polylactic acid using FDM was successful. The in vitro investigation with human fetal osteoblasts showed no cytotoxic effects. Furthermore, FDM does not seem to alter biocompatibility of PLA. Nonetheless osteoblasts showed reduced growth on PLA compared to the polystyrene control within the cell experiments. This could be attributed to surface roughness and possible release of residual monomers. Those influences could be investigated in further studies and thus lead to improvement in the additive manufacturing process. In addition, further research focused on the effect of PLA on bone growth should follow. In summary, PLA processed in Fused Deposition Modelling seems to be an attractive material and method for reconstructive surgery because of their biocompatibility and the possibility to produce individually shaped scaffolds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.