Evidence map›Paper›PMID 28919893›Full record

ArticleFrontiers in immunology2017

RIPK3/Fas-Associated Death Domain Axis Regulates Pulmonary Immunopathology to Cryptococcal Infection Independent of Necroptosis.

Zhenzong Fa, Qun Xie, Wei Fang, Haibing Zhang, Haiwei Zhang, Jintao Xu, Weihua Pan, Jinhua Xu, Michal A Olszewski, Xiaoming Deng and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Inbred Mouse Models inJournal of fungi (Basel, Switzerland) · 2024
    Review
  4. Review
  5. Adaptive immunology ofFrontiers in immunology · 2023
    Review
  6. Article
  7. Frontiers in immunology · 2022
    Article
  8. Links between Infections, Lung Cancer, and the Immune System.International journal of molecular sciences · 2021
    Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Zhenzong FaPLA Key Laboratory of Mycosis, Department of Dermatology and Venereology, Changzheng Hospital, Shanghai, China.
Qun XieDepartment of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, Shanghai, China.
Wei FangShanghai Key Laboratory of Molecular Medical Mycology, Shanghai Institute of Medical Mycology, Second Military Medical University, Shanghai, China.
Haibing ZhangKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Haiwei ZhangKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Jintao XuDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, United States.
Weihua PanPLA Key Laboratory of Mycosis, Department of Dermatology and Venereology, Changzheng Hospital, Shanghai, China.
Jinhua XuDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
Michal A OlszewskiShanghai Key Laboratory of Molecular Medical Mycology, Shanghai Institute of Medical Mycology, Second Military Medical University, Shanghai, China.
Xiaoming DengDepartment of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, Shanghai, China.
Wanqing LiaoPLA Key Laboratory of Mycosis, Department of Dermatology and Venereology, Changzheng Hospital, Shanghai, China.
Huashan Hospital · CNSecond Military Medical University · CNShanghai Institutes for Biological Sciences · CNChanghai Hospital · CNChinese Academy of Sciences · CNMichigan Medicine · USShanghai Changzheng Hospital · CN

Funding

Modulation of Pulmonary Defenses in Pathobiology of Chronic InfectionsI01BX000656 · VA · VETERANS HEALTH ADMINISTRATION · PI OLSZEWSKI, MICHAL A · 2011 to 2025
–
BLR&D Research Career Scientist Award ApplicationIK6BX003615 · VA · VETERANS HEALTH ADMINISTRATION · PI OLSZEWSKI, MICHAL A · 2017 to 2021
–
BLRD VA I01 BX000656BLRD VA IK6 BX003615
6 · The paper itself

Abstract

Fas-associated death domain (FADD) and receptor interacting protein kinase 3 (RIPK3) are multifunctional regulators of cell death and immune response. Using a mouse model of cryptococcal infection, the roles of FADD and RIPK3 in anti-cryptococcal defense were investigated. Deletion of RIPK3 alone led to increased inflammatory cytokine production in the

Indexed as

Cryptococcus neoformansFas-associated death domainimmune responsesinflammationreceptor-interacting serine/threonine kinase 3

Identifiers

PMID28919893
PMCPMC5585137
OpenAlexW2751175162

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.