ArticleFrontiers in aging neuroscience2017
Divergent Roles of Vascular Burden and Neurodegeneration in the Cognitive Decline of Geriatric Depression Patients and Mild Cognitive Impairment Patients.
Article in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Influence of mental health and physical activity on memory complaints in older adults: results from the HUNT study.BMC geriatrics · 2026Article
- Diagnostic accuracy of heart rate variability as a screening tool for mild neurocognitive disorder.Frontiers in aging neuroscience · 2024Article
- White Matter Alterations in Depressive Disorder.Frontiers in immunology · 2022Review
- The Enhanced Interhemispheric Functional Connectivity in the Striatum Is Related to the Cognitive Impairment in Individuals With White Matter Hyperintensities.Frontiers in neuroscience · 2022Article
- Association of Lesion Location and Fatigue Symptoms After Ischemic Stroke: A VLSM Study.Frontiers in aging neuroscience · 2022Article
- Be Fit, Be Sharp, Be Well: The Case for Exercise as a Treatment for Cognitive Impairment in Late-life Depression.Journal of the International Neuropsychological Society : JINS · 2021Review
- Endocytosis-pathway polygenic scores affects the hippocampal network connectivity and individualized identification across the high-risk of Alzheimer's disease.Brain imaging and behavior · 2021Article
- Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives.Frontiers in aging neuroscience · 2020Review
- Enhanced Regional Homogeneity and Functional Connectivity in Subjects With White Matter Hyperintensities and Cognitive Impairment.Frontiers in neuroscience · 2019Article
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9 authors.
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Abstract
Both geriatric depression and mild cognitive impairment (MCI) confer an increased risk for the development of dementia. The mechanisms underlying the development of cognitive impairment in geriatric depression patients remain controversial. The present study aimed to explore the association of cognitive decline with vascular risk, white matter hyperintensity (WMH) burden and hippocampal volume in both remitted geriatric depression (RGD) subjects and amnestic mild cognitive impairment (aMCI) subjects. Forty-one RGD subjects, 51 aMCI subjects, and 64 healthy elderly subjects underwent multimodal MRI scans and neuropsychological tests at both baseline and a 35-month follow-up. According to the changing patterns (declining or stable) of global cognitive function during the follow-up period, each group was further divided into a declining subgroup and a stable subgroup. The Framingham 10-year cardiovascular risk, WMH volume and hippocampal volume were measured to assess vascular pathology and neurodegeneration, respectively. The RGD declining group displayed a higher vascular risk and greater WMH volume than the RGD stable group, whereas no such difference was found in the aMCI subjects. In contrast, the aMCI declining group displayed a smaller left hippocampal volume than the aMCI stable group, whereas no such difference was found in the RGD subjects. Furthermore, greater increases in the WHM volume correlated with greater decreases in global cognitive function in the RGD declining group, and greater decreases in the left hippocampal volume correlated with greater decreases in global cognitive function in the aMCI declining group. In conclusion, the cognitive decline in RGD patients is associated with vascular burden, whereas the cognitive decline in aMCI patients is associated with neurodegeneration. These findings could contribute to a better understanding of the specific mechanisms of the development of dementia in each condition.
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