ArticleJournal of pain research2017
The effect of local/topical analgesics on incisional pain in a pig model.
Article in Journal of pain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Pooled it
- Subcutaneous methadone is not different than transdermal fentanyl for postoperative analgesia in dogs with thoracolumbar disc disease, a prospective, randomised, blinded clinical study.BMC veterinary research · 2025Article
- Peripherally mediated opioid combination therapy in mouse and pig.The journal of pain · 2025Article
- Extended Release of Bupivacaine from Temperature-Responsive PNDJ Hydrogels Improves Postoperative Weight-Bearing in Rabbits Following Knee Surgery.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Mechanical and thermal thresholds before and after application of a conditioning stimulus in healthy Göttingen Minipigs.PloS one · 2024Article
- On determining the mechanical nociceptive threshold in pigs: a reliability study.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Intraoperative abobotulinumtoxinA alleviates pain after surgery and improves general wellness in a translational animal model.Scientific reports · 2022Article
- Wound Healing Efficacy of Rosuvastatin Transethosomal Gel, I Optimal Optimization, Histological and In Vivo Evaluation.Pharmaceutics · 2022Article
- A comprehensive tool box for large animal studies of intervertebral disc degeneration.JOR spine · 2021Article
- Analgesia for Sheep in Commercial Production: Where to Next?Animals : an open access journal from MDPI · 2021Review
- A novel excisional wound pain model for evaluation of analgesics in rats.The Korean journal of pain · 2021Article
- Optimal Methods of Documenting Analgesic Efficacy in Neonatal Piglets Undergoing Castration.Animals : an open access journal from MDPI · 2020Review
- Topical wound anaesthesia: efficacy to mitigate piglet castration pain.Australian veterinary journal · 2020Article
- Early Neonatal Pain-A Review of Clinical and Experimental Implications on Painful Conditions Later in Life.Frontiers in pediatrics · 2020Review
- Open field and a behavior score in PNT model for neuropathic pain in pigs.Journal of pain research · 2018Article
- Local NGF and GDNF levels modulate morphology and function of porcine DRG neurites, In Vitro.PloS one · 2018Article
- Nociceptive and Transcriptomic Responses in a Swine Diabetic Wound Model Treated With a Topical Angiotensin 1 Receptor Antagonist.Nursing researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interest in the development of new topical/local drug administration for blocking pain at peripheral sites, with maximum drug activity and minimal systemic effects, is on the rise. In the review article by Kopsky and Stahl, four critical barriers in the process of research and development of topical analgesics were indicated. The active pharmaceutical ingredient (API) and the formulation are among the major challenges. The road to the development of such drugs passes through preclinical studies. These studies, if planned correctly, should serve as guidance for choosing the right API and formulation. Although rodent models for pain continue to provide valuable data on the mechanisms driving pain, their use in developing topical and localized treatment approaches is limited for technical (intraplate injection area is small) as well as mechanical reasons (non-similarity to human skin and innervation). It has been previously shown that pigs are comparable to humans in ways that make them a better choice for evaluating topical and local analgesics. The aim of this study was to summarize several experiments that used pigs for testing postoperative pain in an incisional pain model (skin incision [SI] and skin and muscle incision [SMI]). At the end of the surgery, the animals were treated with different doses of bupivacaine solution (Marcaine
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.