ArticleJournal of pain research2017
How stable are quantitative sensory testing measurements over time? Report on 10-week reliability and agreement of results in healthy volunteers.
Article in Journal of pain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Reliability of Temporal Summation of Pain in Healthy and Clinical Populations: A Systematic Review and Meta-Analysis.European journal of pain (London, England) · 2025Pooled it
- Within-subject, double-blinded, randomized, and placebo-controlled evaluation of the combined effects of the cannabinoid dronabinol and the opioid hydromorphone in a human laboratory pain model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Short- and long-term impact of remifentanil on thermal detection and pain thresholds after cardiac surgery: A randomised controlled trial.European journal of anaesthesiology · 2019Trial
- Test-Retest Reliability of Perception Threshold Estimation in Small Cutaneous Nerve Fibers: A Methodological Investigation.Muscle & nerve · 2025Article
- What if Horses Were Humans? Comparing Rein Tension and Bit Pressures to Human Pressure Pain Thresholds.Animals : an open access journal from MDPI · 2025Article
- Latent transition analysis of pain phenotypes in people at risk of knee osteoarthritis: The MOST cohort study.Osteoarthritis and cartilage · 2025Article
- Variability in Pain Traits Among Young Individuals with High and Low Pain Sensitivity.Journal of pain research · 2025Article
- Test-retest and interrater reliability of experimental within-subject variability of pain reports as assessed by the focused analgesia selection test.Pain reports · 2024Article
- Reliability of a clinical sensory test battery in patients with spine-related leg and arm pain.European journal of pain (London, England) · 2024Article
- The normative values of pain thresholds in healthy Taiwanese.Brain and behavior · 2024Article
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- Feasibility and acceptability of remote administration of the cold pressor test.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- Test-Retest Reliability of Pain Sensitivity Measures in Individuals with Shoulder Pain.Journal of pain research · 2024Article
- The interrater and test-retest reliability of 3 modalities of quantitative sensory testing in healthy adults and people with chronic low back pain or rheumatoid arthritis.Pain reports · 2023Article
- Intra- and inter-session reliability of electrical detection and pain thresholds of cutaneous and muscle primary afferents in the lower back of healthy individuals.Pflugers Archiv : European journal of physiology · 2023Article
- Biobehavioral Assessments in BACPAC: Recommendations, Rationale, and Methods.Pain medicine (Malden, Mass.) · 2023Article
- Long-term consistency of clinical sensory testing measures for pain assessment.The Korean journal of pain · 2023Article
- Quantitative sensory testing in a magnetic resonance environment: considerations for thermal sensitivity and patient safety.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Preliminary Evidence for the Sequentially Mediated Effect of Racism-Related Stress on Pain Sensitivity Through Sleep Disturbance and Corticolimbic Opioid Receptor Function.The journal of pain · 2023Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundQuantitative sensory testing (QST) is a diagnostic tool for the assessment of the somatosensory system. To establish QST as an outcome measure for clinical trials, the question of how similar the measurements are over time is crucial. Therefore, long-term reliability and limits of agreement of the standardized QST protocol of the German Research Network on Neuropathic Pain were tested.
methodsQST on the lower back and hand dorsum (dominant hand) were assessed twice in 22 healthy volunteers (10 males and 12 females; mean age: 46.6±13.0 years), with sessions separated by 10.0±2.9 weeks. All measurements were performed by one investigator. To investigate long-term reliability and agreement of QST, differences between the two measurements, correlation coefficients, intraclass correlation coefficients (ICCs), Bland-Altman plots (limits of agreement), and standard error of measurement were used.
resultsMost parameters of the QST were reliable over 10 weeks in healthy volunteers: Almost-perfect ICCs were observed for heat pain threshold (hand) and mechanical pain sensitivity (back). Substantial ICCs were observed for heat pain threshold (back), pressure pain threshold (back), mechanical pain sensitivity (hand), and vibration detection threshold (back and hand). Some QST parameters, such as cold detection threshold, exhibited low ICCs, but also very low variability. Generally, QST measures exhibited narrow limits of agreement in the Bland-Altman plots.
conclusionThe standardized QST protocol of the German Research Network on Neuropathic Pain is feasible to be used in treatment trials. Moreover, defining a statistically meaningful change is possible, which is a prerequisite for the use of QST in clinical trials as well as in long-term investigations of disease progression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.