ArticleInternational journal of nanomedicine2017
In vitro and in vivo studies of a novel bacterial cellulose-based acellular bilayer nanocomposite scaffold for the repair of osteochondral defects.
Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Material-Assisted Strategies for Osteochondral Defect Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Pooled it
- Bilayer Scaffolds for Interface Tissue Engineering and Regenerative Medicine: A Systematic Reviews.Advances in experimental medicine and biology · 2021Pooled it
- From Design to Application: Advanced Cellulose Scaffolds for Engineered Tissue Regeneration.Polymers · 2026Review
- An Overview of Approaches and Evaluation Methods for Tissue-Engineered Articular Cartilage Constructs in Animal Models.Annals of biomedical engineering · 2025Review
- Nanofibrous scaffolds for bone and cartilage regeneration.Applied physics reviews · 2025Article
- In vivo imaging of adipose-derived stem cell sheets on biodegradable nonwoven fabric using X-ray CT.Biomedical engineering online · 2024Article
- Osteochondral tissue engineering in translational practice: histological assessments and scoring systems.Frontiers in bioengineering and biotechnology · 2024Review
- Multiphasic scaffolds for the repair of osteochondral defects: Outcomes of preclinical studies.Bioactive materials · 2023Review
- Biomimetic Bilayered Scaffolds for Tissue Engineering: From Current Design Strategies to Medical Applications.Advanced healthcare materials · 2023Review
- Nanocellulose: Recent Advances Toward Biomedical Applications.Small science · 2023Article
- In-situ forming injectable GFOGER-conjugated BMSCs-laden hydrogels for osteochondral regeneration.NPJ Regenerative medicine · 2023Article
- Nanohydroxyapatite-Protein Interface in Composite Sintered Scaffold Influences Bone Regeneration in Rabbit Ulnar Segmental Defect.Journal of materials science. Materials in medicine · 2022Article
- Bacterial Cellulose and Its Applications.Polymers · 2022Review
- Bacterial Cellulose-A Remarkable Polymer as a Source for Biomaterials Tailoring.Materials (Basel, Switzerland) · 2022Review
- Osteochondral tissue engineering: Perspectives for clinical application and preclinical development.Journal of orthopaedic translation · 2021Review
- Efficacy of Bacterial Nanocellulose in Hard Tissue Regeneration: A Review.Materials (Basel, Switzerland) · 2021Review
- From Residues to Added-Value Bacterial Biopolymers as Nanomaterials for Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2021Review
- Challenges and Innovations in Osteochondral Regeneration: Insights from Biology and Inputs from Bioengineering toward the Optimization of Tissue Engineering Strategies.Journal of functional biomaterials · 2021Review
- Nanocellulose-Based Scaffolds for Chondrogenic Differentiation and Expansion.Frontiers in bioengineering and biotechnology · 2021Review
- Antioxidant-antibacterial containing bi-layer scaffolds as potential candidates for management of oxidative stress and infections in wound healing.Journal of materials science. Materials in medicine · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial cellulose (BC) is a naturally occurring nanofibrous biomaterial which exhibits unique physical properties and is amenable to chemical modifications. To explore whether this versatile material can be used in the treatment of osteochondral defects (OCD), we developed and characterized novel BC-based nanocomposite scaffolds, for example, BC-hydroxyapatite (BC-HA) and BC-glycosaminoglycans (BC-GAG) that mimic bone and cartilage, respectively. In vitro biocompatibility of BC-HA and BC-GAG scaffolds was established using osteosarcoma cells, human articular chondrocytes, and human adipose-derived mesenchymal stem cells. On subcutaneous implantation, the scaffolds allowed tissue ingrowth and induced no adverse immunological reactions suggesting excellent in vivo biocompatibility. Implantation of acellular bilayered scaffolds in OCD created in rat knees induced progressive regeneration of cartilage tissue, deposition of extracellular matrix, and regeneration of subchondral bone by the host cells. The results of micro-CT revealed that bone mineral density and ratio of bone volume to tissue volume were significantly higher in animals receiving bilayered scaffold as compared to the control animals. To the best of our knowledge, this study proves for the first time, the functional performance of acellular BC-based bilayered scaffolds. Thus, this strategy has great potential for clinical translation and can be used in repair of OCD.
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Registered trials
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