Evidence map›Paper›PMID 28919745›Full record

ArticleInternational journal of nanomedicine2017

Dose and time effect of CdTe quantum dots on antioxidant capacities of the liver and kidneys in mice.

Jilong Wang, Hubo Sun, Peijun Meng, Mengmeng Wang, Mi Tian, Yamin Xiong, Xueying Zhang, Peili Huang

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. A Review of in vivo Toxicity of Quantum Dots in Animal Models.International journal of nanomedicine · 2023
    Review
  6. Article
  7. Denitrase activity ofExperimental and therapeutic medicine · 2019
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jilong Wang *School of Public Health, Capital Medical University.
Hubo Sun *School of Public Health, Capital Medical University.
Peijun MengSchool of Public Health, Capital Medical University.
Mengmeng WangSchool of Public Health, Capital Medical University.
Mi TianMedical Experiment and Test Center, Capital Medical University, Beijing, People's Republic of China.
Yamin XiongSchool of Public Health, Capital Medical University.
Xueying ZhangSchool of Public Health, Capital Medical University.
Peili HuangSchool of Public Health, Capital Medical University.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although quantum dot (QD)-induced toxicity occurs due to free radicals, generation of oxidative stress mediated by reactive oxygen species (ROS) formation is considered an important mechanism. However, free radical mechanisms are essentially difficult to elucidate at the molecular level because most biologically relevant free radicals are highly reactive and short-lived, making them difficult to directly detect, especially in vivo. Antioxidants play an important role in preventing or, in most cases, limiting the damage caused by ROS. Healthy people and animals possess many endogenous antioxidative substances that scavenge free radicals in vivo to maintain the redox balance and genome integrity. The antioxidant capacity of an organism is highly important but seldom studied. In this study, the dose and time effects of CdTe QDs on the antioxidant capacities of the liver and kidneys were investigated in mice using the electron paramagnetic resonance (EPR) spin-trapping technique. We found that the liver and kidneys of healthy mice contain specific antioxidant capacities that scavenge ·OH and ·O

Indexed as

AnimalsAntioxidantsCadmium CompoundsCatalaseDose-Response Relationship, DrugElectron Spin Resonance SpectroscopyFree RadicalsGlutathioneGlutathione PeroxidaseKidneyLiverMaleMalondialdehydeMiceOxidative StressQuantum DotsAntioxidantsCadmium Compoundscadmium tellurideCatalaseFree RadicalsGlutathioneGlutathione PeroxidaseMalondialdehydeSuperoxide DismutaseTelluriumantioxidative capacityfree radical eliminationhydroxyl radicalquantum dotspin-trappingsuperoxide anion radical

Identifiers

PMID28919745
PMCPMC5590760

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.