Evidence map›Paper›PMID 28919726›Full record

ArticleClinical interventions in aging2017

Gene expression levels of the insulin-like growth factor family in patients with AMD before and after ranibizumab intravitreal injections.

Barbara Strzalka-Mrozik, Malgorzata Kimsa-Furdzik, Adam Kabiesz, Katarzyna Michalska-Malecka, Malgorzata Nita, Urszula Mazurek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical interventions in aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Barbara Strzalka-MrozikDepartment of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland.
Malgorzata Kimsa-FurdzikDepartment of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Adam KabieszUniversity Center for Ophthalmology and Oncology, Independent Public Clinical Hospital, Medical University of Silesia, Katowice, Poland.
Katarzyna Michalska-MaleckaUniversity Center for Ophthalmology and Oncology, Independent Public Clinical Hospital, Medical University of Silesia, Katowice, Poland.
Malgorzata NitaDomestic and Specialized Medicine Centre "Dilmed", Katowice, Poland.
Urszula MazurekDepartment of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland.
Medical University of Silesia · PLChildren's Specialized Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe present study focused on the assessment of the mRNA levels of the insulin-like growth factor (IGF) family in patients with the exudative form of age-related macular degeneration (AMD) before and after ranibizumab intravitreal injections. PATIENTS AND

methodsAn analysis of the expression profile of the IGF family of genes in patients with AMD was carried out using the oligonucleotide microarray and quantitative reverse transcriptase polymerase chain reaction (RT-qPCR) methods.

resultsIn the peripheral blood mononuclear cells (PBMCs) obtained from AMD group receiving ranibizumab compared to the peripheral blood mononuclear cells from AMD group before ranibizumab treatment using oligonucleotide microarray technique, six statistically significant differentially expressed transcripts related to the IGF family were detected (unpaired

conclusionOur results revealed a changed expression of

Indexed as

AgedAged, 80 and overAngiogenesis InhibitorsFemaleGene ExpressionHumansInsulin-Like Growth Factor IIIntravitreal InjectionsLeukocytes, MononuclearMacular DegenerationMaleMiddle AgedRanibizumabRNA, MessengerVisual AcuityAngiogenesis InhibitorsInsulin-Like Growth Factor IIRanibizumabRNA, Messengerage-related macular degenerationIGF familymRNAranibizumab

Identifiers

PMID28919726
PMCPMC5592959
OpenAlexW2752569385

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.