Evidence map›Paper›PMID 28919570›Full record

ArticleWorld neurosurgery2017

Initial Clinical Experience with AView-A Clinical Computational Platform for Intracranial Aneurysm Morphology, Hemodynamics, and Treatment Management.

Jianping Xiang, Nicole Varble, Jason M Davies, Ansaar T Rai, Kenichi Kono, Shin-Ichiro Sugiyama, Mandy J Binning, Rabih G Tawk, Hoon Choi, Andrew J Ringer and 5 more

Abstract readCase ReportsMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World neurosurgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  4. Relationship between haemodynamic changes and outcomes of intracranial aneurysms after implantation of the pipeline embolisation device: a single centre study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jianping XiangToshiba Stroke and Vascular Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA; Department of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, USA.
Nicole VarbleToshiba Stroke and Vascular Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA; Department of Mechanical and Aerospace Engineering, University at Buffalo, State University of New York, Buffalo, New York, USA.
Jason M DaviesDepartment of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, USA; Department of Biomedical Informatics, University at Buffalo, State University of New York, Buffalo, New York, USA.
Ansaar T RaiDepartment of Neurosurgery, West Virginia University, Morgantown, West Virginia, USA.
Kenichi KonoDepartment of Neurosurgery, Wakayama Rosai Hospital, Wakayama, Japan.
Shin-Ichiro SugiyamaDepartment of Neurosurgery, Tohoku University, Sendai, Miyagi, Japan.
Mandy J BinningCapital Institute of Neurosciences, Capital Health Systems, Trenton, New Jersey, USA.
Rabih G TawkDepartment of Neurosurgery, Mayo Clinic, Jacksonville, Florida, USA.
Hoon ChoiDepartment of Neurosurgery, SUNY Upstate University Hospital, Syracuse, New York, USA.
Andrew J RingerDepartment of Neurosurgery, Mayfield Clinic, TriHealth Health System, Cincinnati, Ohio, USA.
Kenneth V SnyderToshiba Stroke and Vascular Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA; Department of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, USA; Department of Radiology, University at Buffalo, State University of New York, Buffalo, New York, USA.
Elad I LevyToshiba Stroke and Vascular Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA; Department of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, USA; Department of Radiology, University at Buffalo, State University of New York, Buffalo, New York, USA.
L Nelson HopkinsToshiba Stroke and Vascular Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA; Department of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, USA; Department of Radiology, University at Buffalo, State University of New York, Buffalo, New York, USA.
Adnan H SiddiquiToshiba Stroke and Vascular Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA; Department of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, USA; Department of Radiology, University at Buffalo, State University of New York, Buffalo, New York, USA.
Hui MengToshiba Stroke and Vascular Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA; Department of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, USA; Department of Mechanical and Aerospace Engineering, University at Buffalo, State University of New York, Buffalo, New York, USA; Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York, USA. Electronic address: huimeng@buffalo.edu.

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Micro-Radiographic Imager for Neuroovascular InterventionsR01EB002873 · NIBIB · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI RUDIN, STEPHEN · 2003 to 2015
$5.6M
Institutional Career DevelopmentKL2TR001413 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DUBOCOVICH, MARGARITA L · 2015 to 2024
$4.2M
Hemodynamic Induction of Pathologic Remodeling Leading to Intracranial AneurysmsR01NS064592 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MENG, HUI · 2009 to 2013
$1.7M
Virtual Intervention of Intracranial AneurysmsR01NS091075 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MENG, HUI · 2015 to 2019
$1.7M
AView: A Bedside Simulation Tool for Neurovascular InterventionR03NS090193 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MENG, HUI · 2015 to 2016
$157k
NCATS NIH HHS KL2 TR001413NCATS NIH HHS UL1 TR001412NIBIB NIH HHS R01 EB002873NINDS NIH HHS R01 NS064592NINDS NIH HHS R01 NS091075NINDS NIH HHS R03 NS090193
6 · The paper itself

Abstract

backgroundThe management of intracranial aneurysm (IA) is challenging. Clinicians often rely on varied and intuitively disparate ways of evaluating rupture risk that may only partially take into account complex hemodynamic and morphologic factors. We developed a prototype of a clinically oriented, streamlined, computational platform, AView, for rapid assessment of hemodynamics and morphometrics in clinical settings. To show the potential clinical utility of AView, we report our initial multicenter experience highlighting the possible advantages of morphologic and hemodynamic analysis of IAs.

methodsAView software was deployed across 8 medical centers (6 in the United States, 2 in Japan). Eight clinicians were trained and used the AView software between September 2012 and January 2013.

resultsWe present 12 illustrative cases that show the potential clinical utility of AView. For all, morphology and hemodynamics, flow visualization, and rupture resemblance score (a surrogate for rupture risk) were provided. In 3 cases, AView could confirm the clinicians' decision to treat; in 3 cases, it could suggest which aneurysms may be at greater risk among multiple aneurysms; in 5 cases, AView could provide additional information for use during treatment decisions for ambiguous situations. In one stent-assisted coiling case, flow visualization predicted that the intuitive choice for stent placement could have resulted in sacrifice of an anterior cerebral artery due to blockage by coils and led clinicians to reconsider treatment plans.

conclusionsAView has the potential to confirm decisions to treat IAs, suggest which among multiple aneurysms to treat, and guide treatment decisions. Furthermore, the flow visualization it affords can inform aneurysm treatment planning and potentially avoid poor outcomes.

Indexed as

Decision Support Systems, ClinicalHemodynamicsImage Interpretation, Computer-AssistedSoftwareAgedCerebral AngiographyCerebral ArteriesComputed Tomography AngiographyDisease ManagementFeasibility StudiesFemaleHumansIntracranial AneurysmJapanMagnetic Resonance AngiographyMaleClinical toolComputational fluid dynamicsDecision-makingHemodynamicsIntracranial aneurysmMorphometricsRupture resemblance score

Identifiers

PMID28919570
PMCPMC5705258

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.