ArticleOsteoarthritis and cartilage2017
Role of subchondral bone properties and changes in development of load-induced osteoarthritis in mice.
Article in Osteoarthritis and cartilage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Bisphosphonates as disease-modifying drugs in osteoarthritis preclinical studies: a systematic review from 2000 to 2020.Arthritis research & therapy · 2021Pooled it
- Micro-CT-based analysis of the murine osteochondral unit: a review and recommendations for standardized subchondral bone assessment.JBMR plus · 2026Review
- Article
- Joint damage is more severe following a single bout than multiple bouts of high magnitude loading in mice.Osteoarthritis and cartilage · 2026Article
- Altered subchondral bone mineral density in painful knee osteoarthritis without cysts: a comparative analysis of lateral and medial regions.BMC musculoskeletal disorders · 2025Article
- Receptor activator of nuclear factor-kappa B ligand-derived microglia healing peptide 1-AcN inhibits osteoarthritis progression in mice.Arthritis research & therapy · 2025Article
- Differential effects of alendronate on chondrocytes, cartilage matrix and subchondral bone structure in surgically induced osteoarthritis in mice.Scientific reports · 2024Article
- PTH treatment before cyclic joint loading improves cartilage health and attenuates load-induced osteoarthritis development in mice.Science advances · 2024Article
- ER stress-induced YAP upregulation leads to chondrocyte phenotype loss in age-related osteoarthritis.Frontiers in pharmacology · 2024Article
- Posttraumatic osteoarthritis: from basic science to clinical implications.OTA international : the open access journal of orthopaedic trauma · 2023Article
- Early knee OA definition-what do we know at this stage? An imaging perspective.Therapeutic advances in musculoskeletal disease · 2023Review
- Contrast-enhanced micro-computed tomography of compartment and time-dependent changes in femoral cartilage and subchondral plate in a murine model of osteoarthritis.Anatomical record (Hoboken, N.J. : 2007) · 2023Article
- Contribution of joint tissue properties to load-induced osteoarthritis.Bone reports · 2022Article
- New insights into the role of matrix metalloproteinase 3 (MMP3) in bone.FASEB bioAdvances · 2022Article
- Accuracy ofFrontiers in endocrinology · 2022Article
- Distinct pathological changes of osteochondral units in early OVX-OA involving TGF-β signaling.Frontiers in endocrinology · 2022Article
- Article
- Early inhibition of subchondral bone remodeling slows load-induced posttraumatic osteoarthritis development in mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Article
- A Non-Invasive Method for Generating the Cyclic Loading-Induced Intra-Articular Cartilage Lesion Model of the Rat Knee.Journal of visualized experiments : JoVE · 2021Article
- NF-κB-mediated effects on behavior and cartilage pathology in a non-invasive loading model of post-traumatic osteoarthritis.Osteoarthritis and cartilage · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveAnimal models recapitulating post-traumatic osteoarthritis (OA) suggest that subchondral bone (SCB) properties and remodeling may play major roles in disease initiation and progression. Thus, we investigated the role of SCB properties and its effects on load-induced OA progression by applying a tibial loading model on two distinct mouse strains treated with alendronate (ALN).
designCyclic compression was applied to the left tibia of 26-week-old male C57Bl/6 (B6, low bone mass) and FVB (high bone mass) mice. Mice were treated with ALN (26 μg/kg/day) or vehicle (VEH) for loading durations of 1, 2, or 6 weeks. Changes in articular cartilage and subchondral and epiphyseal cancellous bone were analyzed using histology and microcomputed tomography.
resultsFVB mice exhibited thicker cartilage, a thicker SCB plate, and higher epiphyseal cancellous bone mass and tissue mineral density than B6 mice. Loading induced cartilage pathology, osteophyte formation, and SCB changes; however, lower initial SCB mass and stiffness in B6 mice did not attenuate load-induced OA severity compared to FVB mice. By contrast, FVB mice exhibited less cartilage damage, and slower-growing and less mature osteophytes. In B6 mice, inhibiting bone remodeling via ALN treatment exacerbated cartilage pathology after 6 weeks of loading, while in FVB mice, inhibiting bone remodeling protected limbs from load-induced cartilage loss.
conclusionsIntrinsically lower SCB properties were not associated with attenuated load-induced cartilage loss. However, inhibiting bone remodeling produced differential patterns of OA pathology in animals with low compared to high SCB properties, indicating that these factors do influence load-induced OA progression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.