Evidence map›Paper›PMID 28919427›Full record

ArticleMechanisms of ageing and development2017

Age-dependent atrial arrhythmic phenotype secondary to mitochondrial dysfunction in Pgc-1β deficient murine hearts.

Haseeb Valli, Shiraz Ahmad, Karan R Chadda, Ali B A K Al-Hadithi, Andrew A Grace, Kamalan Jeevaratnam, Christopher L-H Huang

Open access · hybridAbstract read
In one paragraph

Article in Mechanisms of ageing and development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Feedback contributions to excitation-contraction coupling in native functioning striated muscle.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  6. Cardiomyocyte electrophysiology and its modulation: current views and future prospects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  7. Advances in basic and translational research in atrial fibrillation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  8. Review
  9. Research Progress of Myocardial Fibrosis and Atrial Fibrillation.Frontiers in cardiovascular medicine · 2022
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Ageing inBioscience reports · 2019
    Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Haseeb ValliPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, United Kingdom.
Shiraz AhmadPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, United Kingdom.
Karan R ChaddaPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, United Kingdom; Faculty of Health and Medical Sciences, University of Surrey, GU2 7AL, Guildford, Surrey, United Kingdom.
Ali B A K Al-HadithiPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, United Kingdom.
Andrew A GraceDepartment of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, United Kingdom.
Kamalan JeevaratnamPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, United Kingdom; Faculty of Health and Medical Sciences, University of Surrey, GU2 7AL, Guildford, Surrey, United Kingdom; PU-RCSI School of Medicine, Perdana University, 43400, Serdang, Selangor Darul Ehsan, Malaysia.
Christopher L-H HuangPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, United Kingdom; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, United Kingdom. Electronic address: clh11@cam.ac.uk.
University of Cambridge · GBPerdana University · MY

Funding

British Heart Foundation PG/14/79/31102British Heart Foundation PG/15/12/31280Medical Research Council MR/M001288/1Wellcome TrustWellcome Trust 105727/Z/14/Z
6 · The paper itself

Abstract

introductionAgeing and several age-related chronic conditions including obesity, insulin resistance and hypertension are associated with mitochondrial dysfunction and represent independent risk factors for atrial fibrillation (AF). MATERIALS AND

methodsAtrial arrhythmogenesis was investigated in Langendorff-perfused young (3-4 month) and aged (>12 month), wild type (WT) and peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β RESULTS AND DISCUSSION: The Pgc-1β

Indexed as

Action PotentialsAgingAnimalsArea Under CurveArrhythmias, CardiacAtrial FibrillationElectric StimulationElectrodesElectrophysiologyFibrosisGenotypeHeartHeart AtriaMiceMice, Inbred C57BLMitochondriaNuclear ProteinsPpargc1b protein, mouseTranscription FactorsAction potentialAtrialAtrial fibrillationCardiac arrhythmiasCardiac conductionPeroxisome proliferator activated receptor-γ coactivator-1 (PGC-1)Wavelength

Identifiers

PMID28919427
PMCPMC5652526
OpenAlexW2755215442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.