Evidence map›Paper›PMID 28919328›Full record

ArticleJournal of diabetes and its complications2017

C-peptide levels and the risk of diabetes and pre-diabetes among Chinese women with gestational diabetes.

Ping Yin, Ping Shao, Huikun Liu, Weiqin Li, Leishen Wang, Jing Wang, Shuang Zhang, Junhong Leng, Nan Li, Huiguang Tian and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes and its complications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Biochemical and Molecular Markers Among Prediabetic and Type 2 Diabetes Mellitus Patients.International journal of endocrinology and metabolism · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Ping YinDepartment of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Ping ShaoTianjin Women's and Children's Health Center, Tianjin, China.
Huikun LiuTianjin Women's and Children's Health Center, Tianjin, China.
Weiqin LiTianjin Women's and Children's Health Center, Tianjin, China.
Leishen WangTianjin Women's and Children's Health Center, Tianjin, China.
Jing WangTianjin Women's and Children's Health Center, Tianjin, China.
Shuang ZhangTianjin Women's and Children's Health Center, Tianjin, China.
Junhong LengTianjin Women's and Children's Health Center, Tianjin, China.
Nan LiTianjin Women's and Children's Health Center, Tianjin, China.
Huiguang TianTianjin Women's and Children's Health Center, Tianjin, China.
Xilin YangDepartment of Epidemiology and Biostatistics, Tianjin Medical University, Tianjin, China.
Zhijie YuPopulation Cancer Research Program, Dalhousie University, Halifax, NS, Canada.
Gang HuPennington Biomedical Research Center, Baton Rouge, LA, USA. Electronic address: gang.hu@pbrc.edu.
Tianjin Children's Hospital · CNPennington Biomedical Research Center · USDalhousie University · CATianjin Medical University · CN

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Methylomics of prenatal GDM: Natural history & lifestyle intervention in childrenR01DK100790 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI BACCARELLI, ANDREA, HOU, LIFANG · 2014 to 2017
$2.6M
NIDDK NIH HHS R01 DK100790NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

aimsTo examine the association of connecting peptide (C-peptide) and the risks of postpartum diabetes and pre-diabetes among women with prior gestational diabetes.

methodsA cross-sectional study of 1263 women with prior gestational diabetes was carried out at 1-5years after delivery in Tianjin, China. Logistic regression was used to assess the associations of C-peptide and the risks of diabetes and pre-diabetes.

resultsThe multivariable-adjusted odds ratios based on different levels of C-peptide (0-33%, 34-66%, 67-90%, and >90% as C-peptide cutpoints) were 1.00, 1.93 (95% confidence interval [CI] 0.85-4.39), 2.49 (95% CI 1.06-5.87), and 3.88 (95% CI 1.35-11.1) for diabetes (P for trend <0.0001), and 1.00, 1.66 (95% CI 1.18-2.36), 2.38 (95% CI 1.56-3.62) and 2.35 (95% CI 1.27-4.37) for pre-diabetes (P for trend <0.0001), respectively. Restricted cubic splines models showed a positive linear association of C-peptide as a continuous variable with the risks of type 2 diabetes and pre-diabetes. The positive association was significant when stratified by healthy weight and overweight participants.

conclusionsWe found a positive association between serum C-peptide levels and the risks of diabetes and pre-diabetes among Chinese women with prior gestational diabetes. Our finding suggested that elevated C-peptide levels may be a predictor of diabetes and pre-diabetes.

Indexed as

Up-RegulationAdultBiomarkersChinaC-PeptideCross-Sectional StudiesDiabetes, GestationalDiabetes Mellitus, Type 2Disease SusceptibilityFemaleGlucose IntoleranceHealth SurveysHumansIncidencePrediabetic StatePregnancyBiomarkersC-PeptideC-peptideDiabetesGestational diabetes mellitusPre-diabetesWomen

Identifiers

PMID28919328
PMCPMC5679088
OpenAlexW2749813250

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.