ArticleDevelopmental cell2017
Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors.
Article in Developmental cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- Neural Mechanisms of Heart-Lung Crosstalk in Chronic Heart Failure.Circulation research · 2026Article
- Endosomes: An underappreciated player in cell signal transduction.Fundamental research · 2026Review
- Multiple glycoforms of TrkA interact with N-cadherin during trigeminal ganglion neurodevelopment.Journal of cell science · 2026Article
- Neural Inflammation in Thoracic Dorsal Root Ganglia Mediates Cardiopulmonary Spinal Afferent Sensitization in Chronic Heart Failure.bioRxiv : the preprint server for biology · 2025Article
- Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles.Scientific reports · 2023Article
- Article
- Transcytosis-mediated anterograde transport of TrkA receptors is necessary for sympathetic neuron development and function.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A voyage from the ER: spatiotemporal insights into polarized protein secretion in neurons.Frontiers in cell and developmental biology · 2023Article
- ER and Golgi trafficking in axons, dendrites, and glial processes.Current opinion in cell biology · 2022Review
- Transcytosis and trans-synaptic retention by postsynaptic ErbB4 underlie axonal accumulation of NRG3.The Journal of cell biology · 2022Article
- Spatial regulation of endosomes in growing dendrites.Developmental biology · 2022Review
- The sympathetic nervous system in development and disease.Nature reviews. Neuroscience · 2021Review
- Review
- Experience and activity-dependent control of glucocorticoid receptors during the stress response in large-scale brain networks.Stress (Amsterdam, Netherlands) · 2021Article
- Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers.Developmental cell · 2021Article
- NGF Signaling in Endosomes.Advances in experimental medicine and biology · 2021Article
- Prenylation of Axonally Translated Rac1 Controls NGF-Dependent Axon Growth.Developmental cell · 2020Article
- Spatial control of membrane traffic in neuronal dendrites.Molecular and cellular neurosciences · 2020Review
- Tetraspanin1 promotes NGF signaling by controlling TrkA receptor proteostasis.Cellular and molecular life sciences : CMLS · 2020Article
- SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function.PLoS biology · 2019Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Axonal targeting of signaling receptors is essential for neuronal responses to extracellular cues. Here, we report that retrograde signaling by target-derived nerve growth factor (NGF) is necessary for soma-to-axon transcytosis of TrkA receptors in sympathetic neurons, and we define the molecular underpinnings of this positive feedback regulation that enhances neuronal sensitivity to trophic factors. Activated TrkA receptors are retrogradely transported in signaling endosomes from distal axons to cell bodies, where they are inserted on soma surfaces and promote phosphorylation of resident naive receptors, resulting in their internalization. Endocytosed TrkA receptors are then dephosphorylated by PTP1B, an ER-resident protein tyrosine phosphatase, prior to axonal transport. PTP1B inactivation prevents TrkA exit from soma and causes receptor degradation, suggesting a "gatekeeper" mechanism that ensures targeting of inactive receptors to axons to engage with ligand. In mice, PTP1B deletion reduces axonal TrkA levels and attenuates neuron survival and target innervation under limiting NGF (NGF
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.