Evidence map›Paper›PMID 28918646›Full record

ArticleAIDS research and human retroviruses2017

Depletion of Gut-Resident CCR5

David Merriam, Connie Chen, Gema Méndez-Lagares, Kenneth A Rogers, Anthony J Michaels, Jiangli Yan, Paul Casaz, Keith A Reimann, François Villinger, Dennis J Hartigan-O'Connor

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and human retroviruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

David Merriam1 Department of Medical Microbiology and Immunology and California National Primate Research Center, University of California Davis , Davis, California.
Connie Chen1 Department of Medical Microbiology and Immunology and California National Primate Research Center, University of California Davis , Davis, California.
Gema Méndez-Lagares1 Department of Medical Microbiology and Immunology and California National Primate Research Center, University of California Davis , Davis, California.
Kenneth A Rogers2 New Iberia Research Center, University of Louisiana at Lafayette , New Iberia, Louisiana.
Anthony J Michaels3 MassBiologics, University of Massachusetts Medical School , Boston, Massachusetts.
Jiangli Yan3 MassBiologics, University of Massachusetts Medical School , Boston, Massachusetts.
Paul Casaz3 MassBiologics, University of Massachusetts Medical School , Boston, Massachusetts.
Keith A Reimann3 MassBiologics, University of Massachusetts Medical School , Boston, Massachusetts.
François Villinger2 New Iberia Research Center, University of Louisiana at Lafayette , New Iberia, Louisiana.
Dennis J Hartigan-O'Connor1 Department of Medical Microbiology and Immunology and California National Primate Research Center, University of California Davis , Davis, California.
University of Massachusetts Chan Medical School · USUniversity of Louisiana at Lafayette · USUniversity of California, San Francisco · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Nonhuman Primate Reagent ResourceU24AI126683 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2016 to 2026
$20.1M
Resource for Nonhuman Primate Cell Depleting AntibodiesR24OD010976 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ENGELMAN, KATHLEEN, MAGNANI, DIOGO · 2012 to 2019
$4.7M
Effective lethal agents for CCR5???expressing cellsR21AI116230 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HARTIGAN-O'CONNOR, DENNIS J. · 2014 to 2015
$452k
NIAID NIH HHS R21 AI116230NIAID NIH HHS U24 AI126683NIH HHS P51 OD011107NIH HHS R24 OD010976
6 · The paper itself

Abstract

The HIV reservoir forming at the earliest stages of infection is likely composed of CCR5

Indexed as

AnimalsBacterial ProteinsCell LineChemokine CCL5CHO CellsCricetulusImmunotoxinsIntestinal MucosaLymphocyte DepletionLymphopeniaMacaca mulattaMucous MembraneMutant Chimeric ProteinsReceptors, CCR5Bacterial ProteinsChemokine CCL5ImmunotoxinsMutant Chimeric Proteinspseudomonas exoprotein A protein, Pseudomonas aeruginosaReceptors, CCR5bispecific antibodiesCCR5HIVimmunotoxinsRANTES-PE38SIV

Identifiers

PMID28918646
PMCPMC5684671
OpenAlexW2755443460

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.