ArticleDiabetologia2017
Assessment of glucose regulation in pregnancy after gastric bypass surgery.
Article in Diabetologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Hypoglycemia in Pregnancies Following Gastric Bypass-a Systematic Review and Meta-analysis.Obesity surgery · 2022Pooled it
- Pregnancy after bariatric surgery and adverse perinatal outcomes: A systematic review and meta-analysis.PLoS medicine · 2019Pooled it
- Article
- Maternal Hypoglycemia and Reduced Foetal Growth in Pregnancies Following Roux-en-Y Gastric Bypass: A Prospective Cohort Study.Diabetes, obesity & metabolism · 2026Article
- Pregnancy after bariatric surgery: a point of view on unresolved questions.Journal of endocrinological investigation · 2026Article
- Perinatal Outcomes After Sleeve Gastrectomy Compared to a Matched Control Group.The Australian & New Zealand journal of obstetrics & gynaecology · 2026Article
- The Impact of Overweight and Obesity on Pregnancy: A Narrative Review of Physiological Consequences, Risks and Challenges in Prenatal Care, and Early Intervention Strategies.Current diabetes reports · 2025Review
- The Challenges of Diagnosing Gestational Diabetes after Bariatric Surgery: Where Do We Stand?Obesity facts · 2025Review
- Investigating a New Way to Assess Metabolic Risk in Pregnant Females with Prior RYGB Surgery.Nutrients · 2024Article
- Gestational Diabetes Risk and Low Birth Weight After Metabolic Bariatric Surgery: a Complex Interplay to be Balanced.Obesity surgery · 2024Article
- Pregnancy After Bariatric Surgery-Experience from a Tertiary Center.Obesity surgery · 2024Observational
- Increased glycemic variability in pregnant women with Roux-en-Y gastric bypass compared with sleeve gastrectomy.BMJ open diabetes research & care · 2024Observational
- Impact of bariatric surgery on maternal gestational weight gain and pregnancy outcomes in women with obesity: A population-based cohort study from Qatar.Qatar medical journal · 2024Article
- Comment: pregnancy after bariatric surgery - achievements and open questions.BMC pregnancy and childbirth · 2023Article
- The Interplay of Adipokines, Body Composition and Glucose Homeostasis in Pregnant Women with a History of RYGB Operation.Nutrients · 2023Article
- Pregnancy after Bariatric Surgery: Nutrition Recommendations and Glucose Homeostasis: A Point of View on Unresolved Questions.Nutrients · 2023Article
- TyGIS: improved triglyceride-glucose index for the assessment of insulin sensitivity during pregnancy.Cardiovascular diabetology · 2022Article
- Fetal Growth and Adipose Fat Tissue Trajectories in Twin Pregnancies after Gastric Bypass Surgery.Obesity facts · 2022Article
- Glucose Abnormalities and Inappropriate Weight Gain Predict Negative Pregnancy Outcomes After Gastric Bypass Surgery.Obesity surgery · 2021Article
- Glucose Homeostasis, Fetal Growth and Gestational Diabetes Mellitus in Pregnancy after Bariatric Surgery: A Scoping Review.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisRoux-en-Y gastric bypass (RYGB) surgery is characterised by glycaemic variability. Prospective studies of glucose metabolism in pregnancy after RYGB are not available, therefore this study aimed to evaluate physiological alterations in glucose metabolism in pregnancy following RYGB.
methodsSixty-three pregnant women (25 who underwent RYGB, 19 non-operated obese control women and 19 normal weight control women) were included. Frequently sampled 3 h OGTTs and 1 h IVGTTs were performed between 24 and 28 weeks of gestation and, in a subgroup, were repeated at 3-6 months after delivery.
resultsWe observed major alterations in glucose kinetics during the OGTT, including an early increase in plasma glucose followed by hypoglycaemia in 90% of women who had previously undergone RYGB. The higher degree of glycaemic variability in this group was accompanied by increased insulin, C-peptide and glucagon concentrations after oral glucose load, whereas no differences in insulin response were observed after parenteral glucose administration (RYGB vs normal weight). IVGTT data suggested improved insulin sensitivity (mean difference 0.226 × 10 CONCLUSIONS/
interpretationPregnancies after RYGB are affected by altered postprandial glucose, insulin and C-peptide dynamics. Insulin sensitivity is improved by RYGB, although subtle alterations in beta cell function are observed. Longitudinal studies are needed to assess potential consequences for fetal development and pregnancy outcomes.
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