ArticleThe Journal of thoracic and cardiovascular surgery2018
The association between cardiac physiology, acquired brain injury, and postnatal brain growth in critical congenital heart disease.
Article in The Journal of thoracic and cardiovascular surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Meta-regression of sulcal patterns, clinical and environmental factors on neurodevelopmental outcomes in participants with multiple CHD types.Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Paediatric brain MRI findings following congenital heart surgery: a systematic review.Archives of disease in childhood · 2022Pooled it
- Neonatal brain network integration trajectories predict neurodevelopment in congenital heart disease.Pediatric research · 2026Article
- Brain injury in congenital heart disease: pathophysiology, MRI patterns, and perioperative risk factors.Pediatric research · 2026Review
- Brain volumes in congenital heart disease from childhood to adulthood: A pooled neuroimaging study.Neuroimage. Reports · 2026Article
- Neonatal Brain Network Integration Trajectories Predict Neurodevelopment in Congenital Heart Disease.medRxiv : the preprint server for health sciences · 2026Article
- Effect of Fetal Brain Oxygenation and Volume on Brain Maturation and Neurodevelopmental Outcomes in Congenital Heart Disease.Radiology · 2025Article
- Placental histology, perioperative brain development, and neurodevelopmental outcome at 1 year of age in patients undergoing neonatal cardiac surgery-is there an association?Frontiers in cardiovascular medicine · 2025Article
- Fetal circulatory physiology and brain development in complex congenital heart disease: A multi-modal imaging study.Prenatal diagnosis · 2024Article
- Distinct profiles of cerebral oxygenation in focal vs. secondarily generalized EEG seizures in children undergoing cardiac surgery.Frontiers in neurology · 2024Article
- Critical congenital heart disease beyond HLHS and TGA: neonatal brain injury and early neurodevelopment.Pediatric research · 2023Article
- Individual Assessment of Perioperative Brain Growth Trajectories in Infants With Congenital Heart Disease: Correlation With Clinical and Surgical Risk Factors.Journal of the American Heart Association · 2023Article
- Biological and structural phenotypes associated with neurodevelopmental outcomes in congenital heart disease.Translational pediatrics · 2023Review
- Risk factors of postoperative neurodevelopmental abnormalities in neonates with critical congenital heart disease.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023Article
- Fetal Brain Development in Congenital Heart Disease.The Canadian journal of cardiology · 2023Review
- Neuromonitoring, neuroimaging, and neurodevelopmental follow-up practices in neonatal congenital heart disease: a European survey.Pediatric research · 2023Article
- Risk Factors for Perioperative Brain Lesions in Infants With Congenital Heart Disease: A European Collaboration.Stroke · 2022Article
- Neuroimaging and Cerebrovascular Changes in Fetuses with Complex Congenital Heart Disease.Journal of clinical medicine · 2022Article
- Article
- The Effect of Size and Asymmetry at Birth on Brain Injury and Neurodevelopmental Outcomes in Congenital Heart Disease.Pediatric cardiology · 2022Article
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8 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveTo assess the trajectory of perioperative brain growth in relationship to cardiac diagnosis and acquired brain injuries.
methodsThis was a cohort study of term neonates with hypoplastic left heart syndrome (HLHS) and d-transposition of the great arteries (d-TGA). Subjects underwent magnetic resonance imaging of the brain pre- and postoperatively to determine the severity of brain injury and total and regional brain volumes by the use of automated morphometry. Comparisons were made by cardiac lesion and injury status.
resultsA total of 79 subjects were included (49, d-TGA; 30, HLHS). Subjects with HLHS had more postoperative brain injury (55.6% vs 30.4%, P = .03) and more severe brain injury (moderate-to-severe white matter [WM] injury, P = .01). Total and regional perioperative brain growth was not different by brain injury status (either pre- or postoperative). However, subjects with moderate-to-severe WM injury had a slower rate of brain growth in WM and gray matter compared with those with no injury. Subjects with HLHS had a slower rate of growth globally and in WM and deep gray matter as compared with d-TGA (total brain volume: 12 cm
conclusionsNeonates with HLHS have a slower rate of global and regional brain growth compared with d-TGA, likely related to inherent physiologic differences postoperatively. These findings demonstrate the complex interplay between cardiac lesion, brain injury, and brain growth.
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