ArticleGastroenterology2017
Development and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent Cohorts.
Article in Gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05733130 (Registro Italiano Pancreatite Cronica), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Registro Italiano Pancreatite Cronica
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical Practice Guideline—Acute and Chronic Pancreatitis.Deutsches Arzteblatt international · 2022Guideline
- Integrated transcriptome profiling of plasma exosomes reveals molecular stratification of exocrine and endocrine disorders and S100A8-mediated cell interactions in chronic pancreatitis.Cell discovery · 2025Article
- Chronic and Idiopathic Pancreatitis-A Personalized Treatment Approach.United European gastroenterology journal · 2025Review
- Nutritional status in patients with chronic pancreatitis and liver cirrhosis is related to disease conditions and not dietary habits.Scientific reports · 2024Article
- Management of chronic pancreatitis: recent advances and future prospects.Therapeutic advances in gastroenterology · 2024Review
- An intensified trans-sectoral nutritional intervention in malnourished patients with chronic pancreatitis improves diseases prognosis and identifies potential biomarkers of nutritional status.Frontiers in medicine · 2024Article
- Lived Experience of Hereditary Chronic Pancreatitis - A Qualitative Interview Study.Chronic illness · 2022Article
- Malnutrition Is Highly Prevalent in Patients With Chronic Pancreatitis and Characterized by Loss of Skeletal Muscle Mass but Absence of Impaired Physical Function.Frontiers in nutrition · 2022Article
- Article
- Hereditary pancreatitis in childhood: course of disease and complications.Wiener klinische Wochenschrift · 2021Article
- Imaging of inflammatory disease of the pancreas.The British journal of radiology · 2021Review
- T1 mapping for the diagnosis of early chronic pancreatitis: correlation with Cambridge classification system.The British journal of radiology · 2021Article
- Turkish Gastroenterology Association, Pancreas Study Group, Chronic Pancreatitis Committee Consensus Report.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Article
- T Lymphocytes: A Promising Immunotherapeutic Target for Pancreatitis and Pancreatic Cancer?Frontiers in oncology · 2020Review
- Nutrition and Inflammatory Biomarkers in Chronic Pancreatitis Patients.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2019Article
- Article
- Risk factors and prediction score for chronic pancreatitis: A nationwide population-based cohort study.World journal of gastroenterology · 2018Article
- Vitamins D and K as Factors Associated with Osteopathy in Chronic Pancreatitis: A Prospective Multicentre Study (P-BONE Study).Clinical and translational gastroenterology · 2018Article
- Article
Corrections and comments
- Commented on byReply.2018
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsThe clinical course of chronic pancreatitis is unpredictable. There is no model to assess disease severity or progression or predict patient outcomes.
methodsWe performed a prospective study of 91 patients with chronic pancreatitis; data were collected from patients seen at academic centers in Europe from January 2011 through April 2014. We analyzed correlations between clinical, laboratory, and imaging data with number of hospital readmissions and in-hospital days over the next 12 months; the parameters with the highest degree of correlation were used to develop a 3-stage chronic pancreatitis prognosis score (COPPS). The predictive strength was validated in 129 independent subjects identified from 2 prospective databases.
resultsThe mean number of hospital admissions was 1.9 (95% confidence interval [CI], 1.39-2.44) and 15.2 for hospital days (95% CI, 10.76-19.71) for the development cohort and 10.9 for the validation cohort (95% CI, 7.54-14.30) (P = .08). Based on bivariate correlations, pain (numeric rating scale), level of glycated hemoglobin A1c, level of C-reactive protein, body mass index, and platelet count were used to develop the COPPS system. The patients' median COPPS was 8.9 points (range, 5-14). The system accurately discriminated stages of disease severity (low to high): A (5-6 points), B (7-9), and C (10-15). In Pearson correlation analysis of the development cohort, the COPPS correlated with hospital admissions (0.39; P < .01) and number of hospital days (0.33; P < .01). The correlation was validated in the validation set (Pearson correlation values of 0.36 and 0.44; P < .01). COPPS did not correlate with results from the Cambridge classification system.
conclusionsWe developed and validated an easy to use dynamic multivariate scoring system, similar to the Child-Pugh-Score for liver cirrhosis. The COPPS allows objective monitoring of patients with chronic pancreatitis, determining risk for readmission to hospital and potential length of hospital stay.
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