ArticleNeurotoxicology2018
Polymorphisms in manganese transporters show developmental stage and sex specific associations with manganese concentrations in primary teeth.
Article in Neurotoxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis.Environmental health : a global access science source · 2020Pooled it
- Teeth as bioarchives of metallic trace elements: a systematic review.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Systematic analysis of naturally occurring missense mutations in human manganese transporters: prediction and structural insights.bioRxiv : the preprint server for biology · 2025Article
- Manganese Neurotoxicity and Familial Disorders of Manganese Transport.Annals of the Child Neurology Society · 2025Review
- Studies of Slc30a10 Deficiency in Mice Reveal That Intestinal Iron Transporters Dmt1 and Ferroportin Transport Manganese.Cellular and molecular gastroenterology and hepatology · 2025Article
- Neuronal SLC39A8 deficiency impairs cerebellar development by altering manganese homeostasis.JCI insight · 2024Article
- Manganese transporter SLC30A10 and iron transporters SLC40A1 and SLC11A2 impact dietary manganese absorption.bioRxiv : the preprint server for biology · 2024Article
- Manganese - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2024Article
- Early life manganese exposure and reported attention-related behaviors in Italian adolescents.Environmental epidemiology (Philadelphia, Pa.) · 2023Article
- Manganese efflux transporter SLC30A10 missense polymorphism T95I associated with liver injury retains manganese efflux activity.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Genetics and Epigenetics of Manganese Toxicity.Current environmental health reports · 2022Review
- Sex-dependent metal accumulation and immunoexpression of Hsp70 and Nrf2 in rats' brain following manganese exposure.Environmental toxicology · 2022Article
- Role of excretion in manganese homeostasis and neurotoxicity: a historical perspective.American journal of physiology. Gastrointestinal and liver physiology · 2022Review
- Sex-specific neurotoxic effects of heavy metal pollutants: Epidemiological, experimental evidence and candidate mechanisms.Environmental research · 2021Review
- Metal Exposure and SNCA rs356219 Polymorphism Associated With Parkinson Disease and Parkinsonism.Frontiers in neurology · 2020Article
- The solute carriers ZIP8 and ZIP14 regulate manganese accumulation in brain microvascular endothelial cells and control brain manganese levels.The Journal of biological chemistry · 2019Article
- Manganese transporter Slc30a10 controls physiological manganese excretion and toxicity.The Journal of clinical investigation · 2019Article
- Manganese transporter genetics and sex modify the association between environmental manganese exposure and neurobehavioral outcomes in children.Environment international · 2019Article
- Maternal polymorphisms in glutathione-related genes are associated with maternal mercury concentrations and early child neurodevelopment in a population with a fish-rich diet.Environment international · 2018Article
- Polymorphisms in Manganese TransportersFrontiers in genetics · 2018Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundManganese (Mn) is an essential metal that can become neurotoxic at elevated levels with negative consequences on neurodevelopment. We have evaluated the influence of single nucleotide polymorphisms (SNPs) in Mn transporter genes SLC30A10 and SLC39A8 on Mn concentrations in dentine, a validated biomarker that reflects Mn tissue concentrations early in life.
methodsThe study included 195 children with variable environmental Mn exposure. Mn concentrations in dentine representing fetal, early postnatal and early childhood developmental periods were measured using laser ablation-inductively coupled plasma mass spectrometry. SLC30A10 rs12064812 (T/C) and SLC39A8 rs13107325 (C/T) were genotyped by TaqMan real time PCR and SLC30A10 rs1776029 (G/A) by pyrosequencing; and SNPs were analyzed in association with Mn in dentine.
resultsSLC39A8 rs13107325 rare allele (T) carriers had significantly higher Mn concentrations in postnatal dentine (110%, p=0.008). For all SNPs we also observed non-significant associations with Mn concentrations in dentine in opposite directions for fetal and early postnatal periods. Furthermore, there were significant differences in the influence of SLC30A10 rs1776929 genotypes on Mn concentrations in dentine between sexes. DISCUSSION: The findings from this study indicate that common SNPs in Mn transporters influence Mn homeostasis in early development and may therefore be important to consider in future studies of early life Mn exposure and health effects. Our results also suggest that the influence of these transporters on Mn regulation may differ by developmental stage, as well as between girls and boys.
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