Evidence map›Paper›PMID 28917668›Full record

ArticleThe American journal of pathology2017

Gut Microbe-Mediated Suppression of Inflammation-Associated Colon Carcinogenesis by Luminal Histamine Production.

Chunxu Gao, Bhanu Priya Ganesh, Zhongcheng Shi, Rajesh Rasik Shah, Robert Fultz, Angela Major, Susan Venable, Monica Lugo, Kathleen Hoch, Xiaowei Chen and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.

  1. Anticancer Potential ofInternational journal of molecular sciences · 2026
    Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Gut microbes · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. The role of IL-22 in cancer.Medical oncology (Northwood, London, England) · 2024
    Review
  17. Article
  18. Review
  19. Article
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Chunxu GaoDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Department of Pathology, Texas Children's Hospital, Houston, Texas.
Bhanu Priya GaneshDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Department of Pathology, Texas Children's Hospital, Houston, Texas.
Zhongcheng ShiDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Department of Pathology, Texas Children's Hospital, Houston, Texas.
Rajesh Rasik ShahSection of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Robert FultzDepartment of Pathology, Texas Children's Hospital, Houston, Texas; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, Texas.
Angela MajorDepartment of Pathology, Texas Children's Hospital, Houston, Texas.
Susan VenableDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Department of Pathology, Texas Children's Hospital, Houston, Texas.
Monica LugoDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Department of Pathology, Texas Children's Hospital, Houston, Texas.
Kathleen HochDepartment of Pathology, Texas Children's Hospital, Houston, Texas.
Xiaowei ChenDivision of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Center, Columbia University, New York, New York.
Anthony HaagDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Department of Pathology, Texas Children's Hospital, Houston, Texas.
Timothy C WangDivision of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Center, Columbia University, New York, New York.
James VersalovicDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas; Department of Pathology, Texas Children's Hospital, Houston, Texas. Electronic address: jamesv@bcm.edu.
Baylor College of Medicine · USColumbia University · USTexas Children's Hospital · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
Gut L-Histidine Metabolism and Histamine Signaling in Colonic NeoplasiaU01CA170930 · NCI · BAYLOR COLLEGE OF MEDICINE · PI VERSALOVIC, JAMES · 2013 to 2017
$2.8M
Intestinal Lactobacillus and Mucosal ImmunomodulationR01DK065075 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI VERSALOVIC, JAMES · 2007 to 2010
$1.3M
NCI NIH HHS U01 CA170930NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R01 DK065075
6 · The paper itself

Abstract

Microbiome-mediated suppression of carcinogenesis may open new avenues for identification of therapeutic targets and prevention strategies in oncology. Histidine decarboxylase (HDC) deficiency has been shown to promote inflammation-associated colorectal cancer by accumulation of CD11b

Indexed as

Gastrointestinal MicrobiomeAnimalsCarcinogenesisColorectal NeoplasmsCytokinesGene Expression Regulation, NeoplasticHistamineHistidine DecarboxylaseHumansInflammationIntestinal MucosaLimosilactobacillus reuteriMice, Inbred BALB CModels, BiologicalMyeloid CellsPositron-Emission TomographyCytokinesHistamineHistidine DecarboxylaseReceptors, Histamine H2RNA, Messenger

Identifiers

PMID28917668
PMCPMC5809336
OpenAlexW2755306162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.