Evidence map›Paper›PMID 28917655›Full record

ArticleToxicology2017

Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM

Ziying Hu, Minjie Chen, Huifen Zhou, Anui Tharakan, Xiaoke Wang, Lianglin Qiu, Shuai Liang, Xiaobo Qin, Yuhao Zhang, Wanjun Wang and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Deficiency of interleukin-6 receptor ameliorates PMEcotoxicology and environmental safety · 2022
    Article
  2. Environmental health perspectives · 2021
    Article
  3. Hypothalamic-pituitary-adrenal axis mediates ambient PMEcotoxicology and environmental safety · 2021
    Article
  4. Article
  5. Article
  6. Metabolomics analysis of a mouse model for chronic exposure to ambient PMEnvironmental pollution (Barking, Essex : 1987) · 2019
    Article
  7. Article
  8. Exposure to concentrated ambient PMParticle and fibre toxicology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Ziying HuDepartment of Endocrinology, The People's Hospital of Zhengzhou University (Henan Provincial People's Hospital), Zhengzhou, Henan 450003, China; Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: huziying828@126.com.
Minjie ChenDepartment of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China. Electronic address: MC9888@gmail.com.
Huifen ZhouDepartment of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Pathology, Hubei University of Science and Technology, Xianning, Hubei 437100, China. Electronic address: zhf_198019@163.com.
Anui TharakanDepartment of Otolaryngology, John Hopkins University, Baltimore, MD 21205, USA. Electronic address: anuj.tharakan14@gmail.com.
Xiaoke WangDepartment of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Occupational and Environmental Health, School of Public Health, Nantong University, Nantong 226019, China. Electronic address: wxke111@hotmail.com.
Lianglin QiuDepartment of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Occupational and Environmental Health, School of Public Health, Nantong University, Nantong 226019, China. Electronic address: llqiu@ntu.edu.cn.
Shuai LiangDepartment of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: doctorbach@163.com.
Xiaobo QinDepartment of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: xiaobo_qin0902@163.com.
Yuhao ZhangDepartment of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address: xbtiger2002@163.com.
Wanjun WangDepartment of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China. Electronic address: 16211020017@fudan.edu.cn.
Yanyi XuDepartment of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China. Electronic address: yanyi_xu@fudan.edu.cn.
Zhekang YingDepartment of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China. Electronic address: yingzhekang@hotmail.com.
Fudan University · CNUniversity of Maryland, Baltimore · USHenan Provincial People's Hospital · CNJohns Hopkins University · USNantong University · CNSun Yat-sen University · CN

Funding

Hypothalamic Inflammation and PM2.5 Exposure-Induced Insulin ResistanceR01ES024516 · NIEHS · UNIVERSITY OF MARYLAND BALTIMORE · PI YING, ZHEKANG · 2014 to 2018
$1.5M
NIEHS NIH HHS R01 ES024516
6 · The paper itself

Abstract

backgroundExposure to ambient fine particulate matter (PM METHODS AND

resultsLTα/TNFα/LTβ triple-knockout (TNF/LT KO) and wildtype (WT) mice were exposed to concentrated ambient PM

conclusionThe present study suggests that TNF/LT deficiency influences PM

Indexed as

Gene SilencingAdipose Tissue, BrownAdipose Tissue, WhiteAdiposityAnimalsBiomarkersBlood GlucoseEatingEnergy MetabolismGenotypeGlucose Metabolism DisordersInsulinInsulin ResistanceLipid DropletsLymphotoxin-alphaLymphotoxin-betaBiomarkersBlood GlucoseInsulinLtb protein, mouseLymphotoxin-alphaLymphotoxin-betaParticulate MatterTumor Necrosis Factor-alphaUcp1 protein, mouseUncoupling Protein 1Ambient PM(2.5)InflammationLymphotoxinObesityTumor necrosis factor

Identifiers

PMID28917655
PMCPMC5831254
OpenAlexW2754871715

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.