Evidence map›Paper›PMID 28917161›Full record

SynthesisEuropean psychiatry : the journal of the Association of European Psychiatrists2017

Maternal SSRI exposure increases the risk of autistic offspring: A meta-analysis and systematic review.

S Andalib, M R Emamhadi, S Yousefzadeh-Chabok, S K Shakouri, P F Høilund-Carlsen, M S Vafaee, T M Michel

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European psychiatry : the journal of the Association of European Psychiatrists, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  7. Article
  8. Review
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  10. The Autism Spectrum Disorder and Its Possible Origins in Pregnancy.International journal of environmental research and public health · 2024
    Review
  11. Article
  12. The Roles of Serotonin in Neuropsychiatric Disorders.Cellular and molecular neurobiology · 2022
    Review
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  15. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

S AndalibNeuroscience Research Center, Department of Neurosurgery, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Electronic address: andalib@gums.ac.ir.
M R EmamhadiBrachial Plexus and Peripheral Nerve Injury Center, Guilan University of Medical Sciences, Rasht, Iran.
S Yousefzadeh-ChabokNeuroscience Research Center, Department of Neurosurgery, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
S K ShakouriPhysical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
P F Høilund-CarlsenDepartment of Nuclear Medicine, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
M S VafaeeDepartment of Nuclear Medicine, Odense University Hospital, University of Southern Denmark, Odense, Denmark; Department of Psychiatry, Psychiatry Region of Southern, Odense, Denmark; Research Unit of Psychiatry, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark; Center for Applied Neuroscience, BRIDGE, Odense University Hospital, University of Southern Denmark, Psychiatry in the Region of Southern Denmark, Odense, Denmark; Neurosciences Research Center, Department of Neurology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
T M MichelDepartment of Psychiatry, Psychiatry Region of Southern, Odense, Denmark; Research Unit of Psychiatry, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark; Center for Applied Neuroscience, BRIDGE, Odense University Hospital, University of Southern Denmark, Psychiatry in the Region of Southern Denmark, Odense, Denmark; Neurosciences Research Center, Department of Neurology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSelective serotonin reuptake inhibitors (SSRIs) are the most common antidepressants used to preclude maternal pregnancy depression. There is a growing body of literature assessing the association of prenatal exposure to SSRIs with autism spectrum disorder (ASD). The present systematic review and meta-analysis reviewed the medical literature and pooled the results of the association of prenatal exposure to SSRIs with ASD.

methodsPublished investigations in English by June 2016 with keywords of selective serotonin reuptake inhibitors, SSRI, autism spectrum disorder, ASD, pregnancy, childhood, children, neurodevelopment were identified using databases PubMed and PMC, MEDLINE, EMBASE, SCOPUS, and Google Scholar. Cochran's Q statistic-value (Q), degree of freedom (df), and I

resultsThere was a non-significant heterogeneity for the included studies ([Q=3.61, df=6, P=0.730], I

conclusionThe evidence from the present study suggests that prenatal exposure to SSRIs is associated with a higher risk of ASD.

Indexed as

Antidepressive AgentsAutism Spectrum DisorderChildDepressionDepressive DisorderFemaleHumansMalePregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsSelective Serotonin Reuptake InhibitorsAntidepressive AgentsSelective Serotonin Reuptake InhibitorsASDAutism spectrum disorderChildhoodPregnancySelective serotonin reuptake inhibitorsSSRI

Identifiers

PMID28917161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.