ArticleMolecular imaging and biology2018
Potential Effect of Prolonged Sevoflurane Anesthesia on the Kinetics of [
Article in Molecular imaging and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Impact of Mechanical Ventilation and Anesthesia on PET Tracer Kinetics for Combined PET/fMRI Studies in Rats.Molecular imaging and biology · 2025Article
- Effects of sevoflurane anaesthesia on radioligand binding to monoamine oxidase-B in vivo.British journal of anaesthesia · 2021Article
- Quantitative Rodent Brain Receptor Imaging.Molecular imaging and biology · 2020Review
- Test-Retest Repeatability of [ACS chemical neuroscience · 2020Article
- Characterization of [Molecular imaging and biology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePositron emission tomography (PET) in non-human primates (NHP) is commonly performed under anesthesia, with sevoflurane being a widely used inhaled anesthetic. PET measurement in NHP can be repeated, and a difference in radioligand kinetics has previously been observed between the first and second PET measurement on the same day using sevoflurane anesthesia. In this study, we evaluated the effect of prolonged sevoflurane anesthesia on kinetics and binding potential (BP PROCEDURES: Three cynomolgus monkeys underwent two to three PET measurements with [
resultsIn each NHP, the TTP became shorter in the later PET measurements than in the first one. Across all measurements (n = 8), concentration of sevoflurane correlated with TTP (Spearman's ρ = - 0.79, p = 0.03), but not with BP
conclusionsThese data suggest that sevoflurane affects the shape of TACs but has no evident effect on BP
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.