ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2018
The effects of protein and fiber content on gut structure and function in zebrafish (Danio rerio).
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Anti-inflammatory and protective effects of Aloe vera on intestinal function in zebrafish.Journal of molecular histology · 2026Article
- Convergent digestive adaptation to resource limitation in an insular lizard across a microgeographic archipelago.The Journal of animal ecology · 2026Article
- Impact of dietary composition on behavioural expression and gut microbiome dynamics in zebrafish.Pflugers Archiv : European journal of physiology · 2025Article
- Gum Arabic modulates the microbiota-gut-brain axis and affects general fitness in zebrafish.Scientific reports · 2025Article
- Diet shifts alter the activity and distribution of digestive enzymes in an herbivorous fish.Fish physiology and biochemistry · 2025Article
- How consistent is 'the dynamic gut'? Complex physiological responses to dietary fiber and protein across three rodent species.The Journal of experimental biology · 2025Article
- Effect of dietary interaction of sodium bentonite and litter treated with aluminum sulfate on growth performance, litter quality and serum biochemical indices of Nigerian Noiler birds.Tropical animal health and production · 2025Article
- Dietary modulation shapes gut microbiota and digestive physiology associated with specialized frugivory inFrontiers in microbiology · 2025Article
- Diet and habitat as determinants of intestine length in fishes.Reviews in fish biology and fisheries · 2024Article
- Disentangling the link between zebrafish diet, gut microbiome succession, and Mycobacterium chelonae infection.Animal microbiome · 2023Article
- Exogenous 2-keto-L-gulonic Acid Supplementation as a Novel Approach to Enhancing L-ascorbic Acid Biosynthesis in Zebrafish (Animals : an open access journal from MDPI · 2023Article
- Effect of Early Peptide Diets on Zebrafish Skeletal Development.Biomolecules · 2023Article
- Common laboratory diets differentially influence zebrafish gut microbiome's successional development and sensitivity to pathogen exposure.Research square · 2023Article
- Study on Carbohydrate Metabolism in Adult Zebrafish (Aquaculture nutrition · 2023Article
- Intestinal plasticity and metabolism as regulators of organismal energy homeostasis.Nature metabolism · 2022Review
- Comparative transcriptomics reveal tissue level specialization towards diet in prickleback fishes.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2022Article
- High dietary non-starch polysaccharides detrimental to nutrient digestibility, digestive enzyme activity, growth performance, and intestinal morphology in largemouth bass,Frontiers in nutrition · 2022Article
- Consumer trait responses track change in resource supply along replicated thermal gradients.Proceedings. Biological sciences · 2021Article
- Growth Hormone Overexpression Induces Hyperphagia and Intestinal Morphophysiological Adaptations to Improve Nutrient Uptake in Zebrafish.Frontiers in physiology · 2021Article
- Genomic and biochemical evidence of dietary adaptation in a marine herbivorous fish.Proceedings. Biological sciences · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemical reactor theory (CRT) suggests that the digestive tract functions as a chemical reactor for processing food. Presumably, gut structure and function should match diet to ensure adequate nutrient and energy uptake to maintain performance. Within CRT, dietary biochemical composition is the most important factor affecting gut structure and function in vertebrates. We fed Danio rerio (zebrafish) diets ranging from high- to moderate- to low-quality (i.e., ranging from high-protein, low-fiber to low-protein, high-fiber), and observed how gut length and surface area, as well as the activity levels of digestive enzymes (amylase, maltase, trypsin, aminopeptidase, and lipase) shifted in response to these dietary changes. Fish on the low-quality diet had the longest guts with the largest intestinal epithelial surface area and enterocyte cellular volumes. Fish on the moderate-quality diet had intermediate values of most of these parameters, and fish on the high-quality diet, the lowest. These data largely support CRT. Digestive enzyme activity levels were generally elevated in fish fed the moderate- and low-quality diets, but were highest in the fish fed the moderate-quality diet, suggesting that a diet with protein levels closest to that of the natural diet of D. rerio (they are omnivorous in nature) may elicit the best gut performance. However, fish fed the carnivore diet reached the largest terminal body size. Our results support CRT in terms of gut structure; however, our enzyme results do not necessarily agree with CRT and largely depend on which enzyme is discussed. In particular, the evidence for lipase activities being elevated in the fish fed the low-protein, high-fiber diet perhaps reflects a lipid-scavenging mechanism in fish consuming high-fiber foods rather than CRT.
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Registered trials
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