ReviewReviews in endocrine & metabolic disorders2017
Merkel cell carcinoma: Epidemiology, pathogenesis, diagnosis and therapy.
Review in Reviews in endocrine & metabolic disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Japanese Dermatological Association Guidelines: Clinical Questions of Guidelines for Merkel Cell Carcinoma 2025.The Journal of dermatology · 2025Guideline
- A web-based predictive model for overall survival of patients with cutaneous Merkel cell carcinoma: A population-based study.Frontiers in endocrinology · 2022Trial
- Rapidly Progressive Merkel Cell Carcinoma with Atypical Metastatic Pattern-A Case Report and Brief Literature Review.Diagnostics (Basel, Switzerland) · 2025Article
- A Rare Case of Combined Merkel Cell Cancer and Squamous Cell Carcinoma of the Face in an Older Woman of Southern Italy.Plastic and reconstructive surgery. Global open · 2025Article
- Inpatient prevalence and factors associated with Merkel Cell Carcinoma inpatient hospitalization in the United States.Archives of dermatological research · 2024Observational
- Possible association between polyomaviruses and gastrointestinal complications: a narrative review.Gastroenterology and hepatology from bed to bench · 2024Review
- Critical involvement of circular RNAs in virus-associated cancers.Genes & diseases · 2023Review
- Review
- Large Intestinal Obstruction and Perforation From Metastatic Merkel Cell Carcinoma: A Case Report.Cureus · 2023Article
- Near missed diagnosis of Merkel cell carcinoma in a young immunocompetent woman with a recurrent left-arm mass: A case report.Clinical case reports · 2023Article
- Merkel Cell Carcinoma: Changing Practice Patterns and Impact on Recurrence-Free and Overall Survival at a Single Institution and Nationally.Annals of surgical oncology · 2022Article
- ASO Author Reflections: The Utility of Overall Survival as an Outcome in the Study of Merkel Cell Carcinoma.Annals of surgical oncology · 2022Article
- Merkel cell carcinoma associated with tofacitinib therapy.JAAD case reports · 2021Article
- Case Report: Exceptional Response to Avelumab After Failure of Electrochemotherapy in a Patient With Rapidly Progressive, PD-L1-Negative Merkel Cell Carcinoma.Frontiers in oncology · 2021Article
- Exploring the Prognostic Role of Ki67 Proliferative Index in Merkel Cell Carcinoma of the Skin: Clinico-Pathologic Analysis of 84 Cases and Review of the Literature.Endocrine pathology · 2020Review
- Multidisciplinary Treatment, Including Locoregional Chemotherapy, for Merkel-Polyomavirus-Positive Merkel Cell Carcinomas: Perspectives for Patients Exhibiting Oncogenic Alternative Δ exon 6-7 TrkAIII Splicing of Neurotrophin Receptor Tropomyosin-Related Kinase A.International journal of molecular sciences · 2020Article
- Bone marrow involvement with Merkel cell carcinoma.BMJ case reports · 2020Article
- Merkel Cell Carcinoma and Diagnostic Experience in a Reference Hospital: A Case Series.Case reports in medicine · 2020Article
- Merkel cell polyomavirus detected in head and neck carcinomas from Chile.Infectious agents and cancer · 2020Article
- Extramammary Paget disease shows differential expression of B7 family members B7-H3, B7-H4, PD-L1, PD-L2 and cancer/testis antigens NY-ESO-1 and MAGE-A.Oncotarget · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with a neuroendocrine phenotype. Incidence varies according to the geographic regions but is overall increasing. Different risk factors have been identified namely advanced age, immunosuppression, and ultraviolet light exposure. An association between MCC and polyomavirus infection is known. However, the exact mechanism that leads to carcinogenesis is yet to be fully understood. Surgery when feasible is the recommended treatment for localized disease, followed by adjuvant radiation or chemoradiation. In the metastatic setting, chemotherapy has been the standard treatment. However, two recently published trials with immune checkpoint inhibitors in first and second line showed promising results with a tolerable safety profile and these might become the standard therapy shortly. Somatostatin receptors are expressed in many MCC but such expression is not associated with disease severity. Presently there are no biomarkers predictive of response that could help to better select patients to these new therapies, and additional research is essential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.