ArticleScientific reports2017
The effects of different enrofloxacin dosages on clinical efficacy and resistance development in chickens experimentally infected with Salmonella Typhimurium.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
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- Pharmacokinetic and pharmacodynamic integration and resistance analysis of cefquinome againstFrontiers in microbiology · 2025Article
- Penetration of Enrofloxacin in Aqueous Humour of Avian Eyes.Veterinary sciences · 2022Article
- Enrofloxacin-The Ruthless Killer of Eukaryotic Cells or the Last Hope in the Fight against Bacterial Infections?International journal of molecular sciences · 2022Review
- Validation method for determining enrofloxacin and tylosin levels in broiler liver, kidney, and muscle using high-performance liquid chromatography.Veterinary world · 2022Article
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- PK/PD integration of florfenicol alone and in combination with doxycycline againstFrontiers in veterinary science · 2022Article
- Dose-dependent impact of enrofloxacin on broiler chicken gut resistome is mitigated by synbiotic application.Frontiers in microbiology · 2022Article
- Antibiotic resistome of Salmonella typhi: molecular determinants for the emergence of drug resistance.Frontiers of medicine · 2021Review
- Preparation and Directed Evolution of Anti-Ciprofloxacin ScFv for Immunoassay in Animal-Derived Food.Foods (Basel, Switzerland) · 2021Article
- The modulatory effects of alfalfa polysaccharide on intestinal microbiota and systemic health of Salmonella serotype (ser.) Enteritidis-challenged broilers.Scientific reports · 2021Article
- Enrofloxacin Promotes Plasmid-Mediated Conjugation Transfer of Fluoroquinolone-Resistance GeneFrontiers in microbiology · 2021Article
- Genomic Characterization of a Nalidixic Acid-ResistantFrontiers in veterinary science · 2021Article
- Investigation of the Impacts of Antibiotic Exposure on the Diversity of the Gut Microbiota in Chicks.Animals : an open access journal from MDPI · 2020Article
- Effects of enrofloxacin treatment on the bacterial microbiota of milk from goats with persistent mastitis.Scientific reports · 2020Article
- Article
- The Effects of Flavomycin and Colistin Sulfate Pre-Treatment on Ileal Bacterial Community Composition, the Response toMicroorganisms · 2019Article
- Resistance and Virulence Mechanisms ofAntimicrobial agents and chemotherapy · 2019Article
- In vivo pharmacokinetic/Pharmacodynamic modeling of Enrofloxacin against Escherichia coli in broiler chickens.BMC veterinary research · 2018Article
- Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the optimal dosage which can improve clinical efficacy and minimize resistance, pharmacokinetics/pharmacodynamics model of enrofloxacin was established. Effect of enrofloxacin treatments on clearance of Salmonella in experimentally infected chickens and simultaneously resistance selection in Salmonella and coliforms were evaluated in three treatment groups (100, PK/PD designed dosage of 4, 0.1 mg/kg b.w.) and a control group. Treatment duration was three rounds of 7-day treatment alternated with 7-day withdrawal. Results showed that 100 mg/kg b.w. of enrofloxacin completely eradicated Salmonella, but resistant coliforms (4.0-60.8%) were selected from the end of the second round's withdrawal period till the end of the experiment (days 28-42). PK/PD based dosage (4 mg/kg b.w.) effectively reduced Salmonella for the first treatment duration. However upon cessation of medication, Salmonella repopulated chickens and persisted till the end with reduced susceptibility (MIC
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