ArticleScientific reports2017
Striking diflubenzuron resistance in Culex pipiens, the prime vector of West Nile Virus.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 77 citations in OpenAlex.
- Allelic Survey and Population Genomics in a Hotspot of Diflubenzuron Resistance in the MosquitoInsects · 2026Article
- Synergistic action of different molecular mechanisms causes striking levels of insecticide resistance in the malaria vectorProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Present and Future of Mosquito-Borne Disease Control in Europe with a Specific Focus on the Mediterranean.Insects · 2026Review
- Aedes aegypti strain selected with Bacillus thuringiensis svar. israelensis larvicide for 50 generations remains susceptible and exhibited increased fitness.Parasites & vectors · 2025Article
- Lessons learned exploiting a multi-year large-scale data set derived from operational quality assessment of mosquito larval treatments in rain catch basins.Pest management science · 2025Article
- First report and evidence of multiple origins of diflubenzuron resistance alleles in Culex pipiens mosquito from Cyprus.Parasites & vectors · 2025Article
- Article
- Comparative transcriptomics reveals different profiles between diflubenzuron-resistant and -susceptible phenotypes of the mosquito Culex pipiens.Pest management science · 2025Article
- Widespread Distribution ofInsects · 2025Article
- Integrated de novo transcriptome of Culex pipiens mosquito larvae as a resource for genetic control strategies.Scientific data · 2024Article
- Efficiency assessment of a novel automatic mosquito pupae sex separation system in support of area-wide male-based release strategies.Scientific reports · 2024Article
- [Current Status of Domestic Mosquito Control in 2022].Jugan geon-gang gwa jilbyeong · 2024Article
- Article
- Molecular monitoring of insecticide resistance in major disease vectors in Armenia.Parasites & vectors · 2024Article
- Evaluation of diflubenzuron-verapamil combination strategy for eco-safe management ofFrontiers in physiology · 2024Article
- The power of Drosophila genetics in studying insect toxicology and chemical ecology.Crop health · 2023Review
- Evaluating the Sublethal Effects ofInsects · 2023Article
- Cuticle Modifications and Over-Expression of the Chitin-Synthase Gene in Diflubenzuron-Resistant Phenotype.Insects · 2022Article
- Phenotypic insecticide resistance status of the Culex pipiens complex: a European perspective.Parasites & vectors · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Culex pipiens mosquitoes cause severe nuisance and transmit human diseases including West Nile. Vector control by insecticides is the main tool to prevent these diseases and diflubenzuron is one of the most effective mosquito larvicides used in many places. Here, high levels of resistance were identified in Cx. pipiens from Italy, with a Resistance Ratio of 128 fold. The phenotype was associated with mutations at amino acid I1043 (I1043M and I1043L) of the Chitin synthase gene, which showed significantly higher frequency in bioassay survivors. Both mutations have been introduced in the Drosophila melanogaster chitin synthase gene using the genome editing method CRISPR/Cas9 and validated to confer significant levels of resistance, although at different levels. The I→M mutation results in a Resistance Ratio >2,900 fold and the I→L mutation >20 fold. Two PCR based diagnostics were developed for monitoring of the resistant mutations in field populations. The findings are of major concern for public health given the importance of diflubenzuron in mosquito control in many places, the intensity of the resistance phenotype and the limited availability of alternative larvicides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.