ArticleScientific reports2017
Local Juvenile Hormone activity regulates gut homeostasis and tumor growth in adult Drosophila.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Meta-Analysis of Public RNA Sequencing Data Revealed Potential Key Genes Associated with Reproductive Division of Labor in Social Hymenoptera and Termites.International journal of molecular sciences · 2023Pooled it
- Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage ineLife · 2026Article
- Preparing for parenthood: molecular reprogramming precedes parenting in the burying beetle Nicrophorus vespilloides.Frontiers in zoology · 2026Article
- Two cytochrome P450 epoxidases mediate juvenile hormone biosynthesis in Drosophila melanogaster.Insect biochemistry and molecular biology · 2026Article
- Two cytochrome P450 epoxidases mediate juvenile hormone biosynthesis inbioRxiv : the preprint server for biology · 2025Article
- Genetic and behavioral analyses suggest that larval and adult stages of Lucilia cuprina employ different sensory systems to detect rotten beef.Parasites & vectors · 2025Article
- Genome-Wide Profiling of P450 Gene Expression Reveals Caste-Specific and Developmental Patterns inInternational journal of molecular sciences · 2025Article
- Post-eclosion growth in the Drosophila ejaculatory duct is driven by Juvenile hormone signaling and is essential for male fertility.Developmental biology · 2025Article
- Drosophila Intestine as a Model to Study Tumors.Advances in experimental medicine and biology · 2025Review
- Exploring the midgut physiology of the non-haematophagous mosquitoOpen biology · 2024Article
- The intestinal stem cell/enteroblast-GAL4 driver, escargot-GAL4, also manipulates gene expression in the juvenile hormone-synthesizing organ of Drosophila melanogaster.Scientific reports · 2024Article
- Cellular and molecular organization of the Drosophila foregut.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Juvenile hormones direct primordial germ cell migration to the embryonic gonad.Current biology : CB · 2024Article
- Intestinal Immune Deficiency and Juvenile Hormone Signaling Mediate a Metabolic Trade-off in AdultMetabolites · 2023Article
- Recovery from cold-induced reproductive dormancy is regulated by temperature-dependent AstC signaling.Current biology : CB · 2022Article
- The molecular interplay of the establishment of an infection - gene expression of Diaphorina citri gut and Candidatus Liberibacter asiaticus.BMC genomics · 2021Article
- Hidden genomic features of an invasive malaria vector, Anopheles stephensi, revealed by a chromosome-level genome assembly.BMC biology · 2021Article
- Metabolic Signatures of Life Span Regulated by Mating, Sex Peptide, and Mifepristone/RU486 in Female Drosophila melanogaster.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- What happens after a blood meal? A transcriptome analysis of the main tissues involved in egg production in Rhodnius prolixus, an insect vector of Chagas disease.PLoS neglected tropical diseases · 2020Article
- Transcriptome Analysis and Knockdown of the Juvenile Hormone Esterase Gene Reveal Abnormal Feeding Behavior in the Sugarcane Giant Borer.Frontiers in physiology · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hormones play essential roles during development and maintaining homeostasis in adult organisms, regulating a plethora of biological processes. Generally, hormones are secreted by glands and perform a systemic action. Here we show that Juvenile Hormones (JHs), insect sesquiterpenoids synthesized by the corpora allata, are also synthesized by the adult Drosophila gut. This local, gut specific JH activity, is synthesized by and acts on the intestinal stem cell and enteroblast populations, regulating their survival and cellular growth through the JH receptors Gce/Met and the coactivator Tai. Furthermore, we show that this local JH activity is important for damage response and is necessary for intestinal tumor growth driven by activating mutations in Wnt and EGFR/Ras pathways. Together, our results identify JHs as key hormonal regulators of gut homeostasis and open the possibility that analogous hormones may play a similar role in maintaining vertebrate adult intestinal stem cell population and sustaining tumor growth.
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