Evidence map›Paper›PMID 28916794›Full record

SynthesisScientific reports2017

Association among obesity, overweight and autism spectrum disorder: a systematic review and meta-analysis.

Zhen Zheng, Li Zhang, Shiping Li, Fengyan Zhao, Yan Wang, Lan Huang, Jinglan Huang, Rong Zou, Yi Qu, Dezhi Mu

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 5 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 5 syntheses or guidelines pooled it, 132 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Zhen ZhengDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Li ZhangDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Shiping LiDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Fengyan ZhaoDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Yan WangDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Lan HuangDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Jinglan HuangDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Rong ZouDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Yi QuDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Dezhi MuDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, China. mudz@scu.edu.cn.
Sichuan University · CNWest China Second University Hospital of Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity, overweight and autism spectrum disorder (ASD) remain serious public health problems. Although lots of studies have recently explored the association among obesity, overweight and ASD, the findings are inconsistent. Thus, we conducted a meta-analysis of epidemiological studies to examine the association among obesity, overweight and ASD. PubMed, Embase, and the Cochrane Library were used for literature searches to identify eligible studies published in English before November 15, 2016. Relevant studies estimating the association among obesity, overweight and ASD were included. Fifteen studies encompassing 49,937,078 participants and 1,045,538 individuals with ASD were included in this study. A random effects model was chosen to synthesize the effect sizes of individual studies. The prevalence of obesity was significantly higher in individuals with ASD than in controls (OR = 1.84, 95% confidence interval [CI]: 1.37-2.48, P < 0.001). However, the prevalence of overweight in individuals with ASD was not significantly different from that in controls (OR = 1.07, 95% CI: 0.83-1.38, P = 0.62). Both sensitivity analysis and publication bias testing revealed that the findings were robust. The meta-analysis showed a significant association between obesity and ASD. However, no significant association was identified between overweight and ASD.

Indexed as

Autism Spectrum DisorderFemaleHumansMaleObesityOdds RatioOverweightPrevalencePublication BiasResearch Design

Identifiers

PMID28916794
PMCPMC5601947
OpenAlexW2754116193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.