Evidence map›Paper›PMID 28916742›Full record

ArticleScientific reports2017

Haplotype of the Interleukin 17A gene is associated with osteitis after Bacillus Calmette-Guerin vaccination.

Matti Korppi, Johanna Teräsjärvi, Milla Liehu-Martiskainen, Eero Lauhkonen, Juho Vuononvirta, Kirsi Nuolivirta, Liisa Kröger, Laura Pöyhönen, Minna K Karjalainen, Qiushui He

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Polymorphisms inCancer control : journal of the Moffitt Cancer Center
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Matti KorppiCenter for Child Health Research, University of Tampere and University Hospital, Tampere, Finland. matti.korppi@staff.uta.fi.
Johanna TeräsjärviDepartment of Medical Microbiology and Immunology, University of Turku, Turku, Finland.
Milla Liehu-MartiskainenCenter for Child Health Research, University of Tampere and University Hospital, Tampere, Finland.
Eero LauhkonenCenter for Child Health Research, University of Tampere and University Hospital, Tampere, Finland.
Juho VuononvirtaDepartment of Medical Microbiology and Immunology, University of Turku, Turku, Finland.
Kirsi NuolivirtaDepartment of Pediatrics, Seinäjoki Central Hospital, Seinäjoki, Finland.ORCID 0000-0002-2612-9449
Liisa KrögerDepartment of Pediatrics, Kuopio University Hospital, Kuopio, Finland.
Laura PöyhönenSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Minna K KarjalainenPEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, Oulu, Finland.
Qiushui HeDepartment of Medical Microbiology and Immunology, University of Turku, Turku, Finland.
Tampere University Hospital · FIUniversity of Turku · FIKuopio University Hospital · FIOulu University Hospital · FIRockefeller University · USSeinäjoki University of Applied Sciences · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacillus Calmette-Guerin (BCG) osteitis was more common in Finland than elsewhere at the time when universal BCG vaccinations were given to Finnish newborns. There is evidence that IL-17 plays a role in the defense against tuberculosis. The aim of this study was to evaluate the associations of IL17A rs4711998, IL17A rs8193036 and IL17A rs2275913 single-nucleotide polymorphisms (SNPs) with the risk of BCG osteitis after newborn vaccination. IL17A rs4711998, rs8193036 and rs2275913 SNPs were determined in 131 adults had presented with BCG osteitis after newborn BCG vaccination. We analyzed, using the HaploView and PLINK programs, whether allele or haplotype frequencies of these SNPs differ between the former BCG osteitis patients and Finnish population controls. Of the three IL17A SNPs studied, rs4711998 associated nominally with BCG osteitis; minor allele frequency was 0.215 in 130 BCG osteitis cases and 0.298 in 99 controls (p = 0.034). Frequency of the second common haplotype (GTA) differed significantly between BCG osteitis cases and controls (0.296 vs. 0.184, p = 0.040 after multi-testing correction). The GTA haplotype of the IL17A SNPs rs4711998, rs8193036 and rs2275913 was associated with osteitis after BCG vaccination.

Indexed as

Genetic Predisposition to DiseaseHaplotypesBCG VaccineFinlandHumansInterleukin-17Mycobacterium bovisOsteitisPolymorphism, Single NucleotideVaccinationBCG VaccineIL17A protein, humanInterleukin-17

Identifiers

PMID28916742
PMCPMC5601914
OpenAlexW2755268649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.