Evidence map›Paper›PMID 28916732›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

IL-4-producing B cells regulate T helper cell dichotomy in type 1- and type 2-controlled diseases.

Ramona Hurdayal, Hlumani H Ndlovu, Mélanie Revaz-Breton, Suraj P Parihar, Justin Komguep Nono, Melissa Govender, Frank Brombacher

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Review
  3. Adoptive Transfer of B Cells In Vivo for Assessment of Their Immune Function.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  4. Review
  5. Article
  6. B Cell IL-4 Drives Th2 ResponsesFrontiers in immunology · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Immunobiology of T Cells in Sjögren's Syndrome.Clinical reviews in allergy & immunology · 2021
    Review
  11. Article
  12. Article
  13. Article
  14. B cell-derived IL-1β and IL-6 drive T cell reconstitution following lymphoablation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Article
  15. Article
  16. Review
  17. Article
  18. B Cells Inhibit CD4Infection and immunity · 2020
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Ramona HurdayalInstitute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC), Immunology of Infectious Diseases, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.
Hlumani H NdlovuInstitute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC), Immunology of Infectious Diseases, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.
Mélanie Revaz-BretonInstitute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC), Immunology of Infectious Diseases, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.
Suraj P PariharInstitute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC), Immunology of Infectious Diseases, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.
Justin Komguep NonoInstitute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC), Immunology of Infectious Diseases, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.
Melissa GovenderInstitute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC), Immunology of Infectious Diseases, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.
Frank BrombacherInstitute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC), Immunology of Infectious Diseases, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa; brombacherfrank@gmail.com.
South African Medical Research Council · ZAUniversity of Cape Town · ZAInternational Centre for Genetic Engineering and Biotechnology · ZAMinistry of Scientific Research and Innovation · CM

Funding

Wellcome Trust 084323
6 · The paper itself

Abstract

Interleukin-4 (IL-4)-induced T helper (Th) 2 cells promote susceptibility to the protozoan parasite

Indexed as

AnimalsB-LymphocytesCells, CulturedInterleukin-4Leishmania majorLeishmaniasis, CutaneousMiceMice, Inbred BALB CMice, Inbred C57BLReceptors, Interleukin-4Schistosoma mansoniSchistosomiasisSignal TransductionT-Lymphocytes, Helper-InducerInterleukin-4Receptors, Interleukin-4B cellsIL-4R alphaleishmaniasismouseschistosomiasis

Identifiers

PMID28916732
PMCPMC5635893
OpenAlexW2756409646

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.