ArticleThe Journal of rheumatology2017
Genetic Determinants of Radiographic Knee Osteoarthritis in African Americans.
Open access · greenAbstract read
In one paragraph
Article in The Journal of rheumatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Racial-Ethnic Differences in Osteoarthritis Pain and Disability: A Meta-Analysis.The journal of pain · 2019Pooled it
- Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.Nature genetics · 2018Pooled it
- Cannabidiol Is a Potential Inhibitor of Ferroptosis in Human Articular Chondrocytes.Journal of cellular and molecular medicine · 2025Article
- The association between the uric acid-to-high-density lipoprotein cholesterol ratio and osteoarthritis risk in U.S. adults: a cross-sectional study based on NHANES 1999-2016.Lipids in health and disease · 2025Article
- Clinical and omics biomarkers in osteoarthritis diagnosis and treatment.Journal of orthopaedic translation · 2025Review
- The Genetic Markers of Knee Osteoarthritis in Women from Russia.Biomedicines · 2024Article
- Intergenic Interactions ofLife (Basel, Switzerland) · 2023Article
- The Role Played by Ferroptosis in Osteoarthritis: Evidence Based on Iron Dyshomeostasis and Lipid Peroxidation.Antioxidants (Basel, Switzerland) · 2022Review
- Multi-omics molecular biomarkers and database of osteoarthritis.Database : the journal of biological databases and curation · 2022Article
- Genetics of osteoarthritis.Osteoarthritis and cartilage · 2022Review
- The Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis.Calcified tissue international · 2021Review
- Expression profiles of long non-coding RNAs in the cartilage of patients with knee osteoarthritis and normal individuals.Experimental and therapeutic medicine · 2021Article
- Article
- Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis.Bone research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Youfang LiuFrom the Thurston Arthritis Research Center, and the Department of Radiology, and the Departments of Medicine and Orthopaedics, University of North Carolina, Chapel Hill, North Carolina; Departments of Medicine and Epidemiology and Public Health, University of Maryland School of Medicine; Medical Care Clinical Center, Veterans Affairs Maryland Health Care System; Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Baltimore, Maryland; Institute for Aging Research, Hebrew SeniorLife; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts; Translational Genomics Research Institute, Phoenix, Arizona; Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA.
Michelle S YauFrom the Thurston Arthritis Research Center, and the Department of Radiology, and the Departments of Medicine and Orthopaedics, University of North Carolina, Chapel Hill, North Carolina; Departments of Medicine and Epidemiology and Public Health, University of Maryland School of Medicine; Medical Care Clinical Center, Veterans Affairs Maryland Health Care System; Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Baltimore, Maryland; Institute for Aging Research, Hebrew SeniorLife; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts; Translational Genomics Research Institute, Phoenix, Arizona; Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA. michelleyau@hsl.harvard.edu.
Laura M Yerges-ArmstrongFrom the Thurston Arthritis Research Center, and the Department of Radiology, and the Departments of Medicine and Orthopaedics, University of North Carolina, Chapel Hill, North Carolina; Departments of Medicine and Epidemiology and Public Health, University of Maryland School of Medicine; Medical Care Clinical Center, Veterans Affairs Maryland Health Care System; Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Baltimore, Maryland; Institute for Aging Research, Hebrew SeniorLife; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts; Translational Genomics Research Institute, Phoenix, Arizona; Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA.
David J DugganFrom the Thurston Arthritis Research Center, and the Department of Radiology, and the Departments of Medicine and Orthopaedics, University of North Carolina, Chapel Hill, North Carolina; Departments of Medicine and Epidemiology and Public Health, University of Maryland School of Medicine; Medical Care Clinical Center, Veterans Affairs Maryland Health Care System; Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Baltimore, Maryland; Institute for Aging Research, Hebrew SeniorLife; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts; Translational Genomics Research Institute, Phoenix, Arizona; Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA.
Jordan B RennerFrom the Thurston Arthritis Research Center, and the Department of Radiology, and the Departments of Medicine and Orthopaedics, University of North Carolina, Chapel Hill, North Carolina; Departments of Medicine and Epidemiology and Public Health, University of Maryland School of Medicine; Medical Care Clinical Center, Veterans Affairs Maryland Health Care System; Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Baltimore, Maryland; Institute for Aging Research, Hebrew SeniorLife; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts; Translational Genomics Research Institute, Phoenix, Arizona; Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA.
Marc C HochbergFrom the Thurston Arthritis Research Center, and the Department of Radiology, and the Departments of Medicine and Orthopaedics, University of North Carolina, Chapel Hill, North Carolina; Departments of Medicine and Epidemiology and Public Health, University of Maryland School of Medicine; Medical Care Clinical Center, Veterans Affairs Maryland Health Care System; Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Baltimore, Maryland; Institute for Aging Research, Hebrew SeniorLife; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts; Translational Genomics Research Institute, Phoenix, Arizona; Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA.
Braxton D MitchellFrom the Thurston Arthritis Research Center, and the Department of Radiology, and the Departments of Medicine and Orthopaedics, University of North Carolina, Chapel Hill, North Carolina; Departments of Medicine and Epidemiology and Public Health, University of Maryland School of Medicine; Medical Care Clinical Center, Veterans Affairs Maryland Health Care System; Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Baltimore, Maryland; Institute for Aging Research, Hebrew SeniorLife; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts; Translational Genomics Research Institute, Phoenix, Arizona; Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA.
Rebecca D JacksonFrom the Thurston Arthritis Research Center, and the Department of Radiology, and the Departments of Medicine and Orthopaedics, University of North Carolina, Chapel Hill, North Carolina; Departments of Medicine and Epidemiology and Public Health, University of Maryland School of Medicine; Medical Care Clinical Center, Veterans Affairs Maryland Health Care System; Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Baltimore, Maryland; Institute for Aging Research, Hebrew SeniorLife; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts; Translational Genomics Research Institute, Phoenix, Arizona; Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA.
Joanne M JordanFrom the Thurston Arthritis Research Center, and the Department of Radiology, and the Departments of Medicine and Orthopaedics, University of North Carolina, Chapel Hill, North Carolina; Departments of Medicine and Epidemiology and Public Health, University of Maryland School of Medicine; Medical Care Clinical Center, Veterans Affairs Maryland Health Care System; Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Baltimore, Maryland; Institute for Aging Research, Hebrew SeniorLife; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts; Translational Genomics Research Institute, Phoenix, Arizona; Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA.
University of Maryland, Baltimore · USHebrew SeniorLife · US
Funding
University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9MResearch BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3MRESEARCH TRAINING IN THE EPIDEMIOLOGY OF AGINGT32AG000262 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ANN L GRUBER-BALDINI, DENISE L ORWIG · 1998 to 2026
$8.2MTranslational Researchin Aging Trainnig ProgramT32AG023480 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI LIPSITZ, LEWIS · 2004 to 2024
$7.6MProject 3P60AR049465 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JORDAN, JOANNE M. · 2003 to 2008
$6.0MGenome-wide Association Study to Identify Genetic Components of Knee OA: The OAIRC2AR058950 · NIAMS · OHIO STATE UNIVERSITY · PI DUGGAN, DAVID J, HOCHBERG, MARC C. · 2009 to 2010
$4.4MJohnston County Osteoarthritis Project: Arthritis, Disability, and Other Chronic DiseasesU01DP006266 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NELSON, AMANDA E · 2016 to 2020
$3.8MWomen's knee motion patterns in functional activitiesP60AR030701 · NIAMS · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI WINFIELD, JOHN B · 1986 to 2001
$1.9M CLINICAL CENTER FOR THE OSTEOARTHRITIS-264022262-264022262N01AR022262 · NIAMS · THE MEMORIAL HOSPITAL · PI ASSAF, ANNLOUISE R. · 2002 to 2006
–CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22261N01AR022261 · NIAMS · OHIO STATE UNIVERSITY RESEARCH · PI JACKSON, REBECCA · 2002 to 2006
–CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22260N01AR022260 · NIAMS · UNIVERSITY OF PITTSBURGH · PI KWOH, KENT · 2002 to 2006
–CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-264022259-264022259N01AR022259 · NIAMS · UNIVERSITY OF MARYLAND AT BALT · PI HOCHBERG, MARC C. · 2002 to 2006
–NCCDPHP CDC HHS U01 DP006266NIAMS NIH HHS N01 AR022258NIAMS NIH HHS N01 AR022259NIAMS NIH HHS N01 AR022260NIAMS NIH HHS N01 AR022261NIAMS NIH HHS N01 AR022262NIAMS NIH HHS P60 AR030701NIAMS NIH HHS P60 AR049465NIAMS NIH HHS RC2 AR058950NIA NIH HHS P30 AG028747NIA NIH HHS T32 AG000262NIA NIH HHS T32 AG023480NIDDK NIH HHS P30 DK072488
Abstract
objectiveThe etiology of knee osteoarthritis (OA), the most common form of arthritis, is complex and may differ by race or ethnicity. In recent years, genetic studies have identified many genetic variants associated with OA, but nearly all the studies were conducted in European whites and Asian Americans. Few studies have focused on the genetics of knee OA in African Americans.
methodsWe performed a genome-wide association study of radiographic knee OA in 1217 African Americans from 2 North American cohort studies: 590 subjects from the Johnston County Osteoarthritis Project and 627 subjects from the Osteoarthritis Initiative. Analyses were conducted in each cohort separately and combined in an inverse variance fixed effects metaanalysis, which were then included in pathway analyses. We additionally tested 12 single-nucleotide polymorphisms robustly associated with OA in European white populations for association in African Americans.
resultsWe identified a genome-wide significant variant in
conclusionThese results highlight differences in the genetic architecture of knee OA between African American and European whites. This finding underscores the need to include more diverse populations in OA genetics studies.
Indexed as
Polymorphism, Single NucleotideAgedAllelesBlack or African AmericanFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansKnee JointMaleMiddle AgedOsteoarthritis, KneeRNA, Long NoncodingTomography, X-Ray ComputedWhite PeopleRNA, Long NoncodingETHNICITYGENETICSGENOME-WIDE ASSOCIATION STUDYKNEE OSTEOARTHRITIS
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.