ArticleThe Journal of rheumatology2017
Serologic Evidence of Gut-driven Systemic Inflammation in Juvenile Idiopathic Arthritis.
Article in The Journal of rheumatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Probiotic supplementation increases fecal TLR4 agonists without improving disease activity in juvenile idiopathic arthritis: a randomized placebo-controlled trial.Gut microbes · 2026Trial
- The gut-joint axis in juvenile idiopathic arthritis.Arthritis research & therapy · 2026Review
- Host genetic variation and gut microbiome in pediatric diseases.Chinese medical journal · 2026Review
- An etiopathogenesis of juvenile idiopathic arthritis: the protein-homeostasis-system hypothesis.Frontiers in pediatrics · 2026Review
- Regional Gastrointestinal Permeability Patterns in Juvenile Idiopathic Arthritis: A Window into Subclinical Inflammation and Microbiota-Driven Disease Mechanisms.Children (Basel, Switzerland) · 2025Article
- Current Challenges inMicroorganisms · 2025Review
- Quantification of Enteric Dysfunction in Cystic Fibrosis: Inter- and Intraindividual Variability.The Journal of pediatrics · 2024Article
- Lipopolysaccharide-binding protein and future Parkinson's disease risk: a European prospective cohort.Journal of neuroinflammation · 2023Article
- Infant gut microbiota and environment associate with juvenile idiopathic arthritis many years prior to disease onset, especially in genetically vulnerable children.EBioMedicine · 2023Article
- Duodenojejunal inflammation causing chronic vomiting in adult-onset Still's disease.BMJ case reports · 2023Article
- Recent advances in systemic lupus erythematosus and microbiota: from bench to bedside.Frontiers of medicine · 2022Review
- Antibodies RecognizingJournal of immunology research · 2022Article
- Rhamnose Is Superior to Mannitol as a Monosaccharide in the Dual Sugar Absorption Test: A Prospective Randomized Study in Children With Treatment-Naïve Celiac Disease.Frontiers in pediatrics · 2022Article
- Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease.Med (New York, N.Y.) · 2021Article
- Systemic Proteomic Analysis Reveals Distinct Exosomal Protein Profiles in Rheumatoid Arthritis.Journal of immunology research · 2021Observational
- Intestinal Barrier Dysfunction, LPS Translocation, and Disease Development.Journal of the Endocrine Society · 2020Article
- Systemic Lupus Erythematosus and dysbiosis in the microbiome: cause or effect or both?Current opinion in immunology · 2019Review
- Transdermal fluorescence detection of a dual fluorophore system for noninvasive point-of-care gastrointestinal permeability measurement.Biomedical optics express · 2019Article
- Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis.JCI insight · 2019Article
- Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal.Annals of the rheumatic diseases · 2019Article
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
Abstract
objectiveAccumulating evidence links juvenile idiopathic arthritis (JIA) to nonhost factors such as gut microbes. We hypothesize that children with new-onset JIA have increased intestinal bacterial translocation and circulating lipopolysaccharide (LPS).
methodsWe studied systemic treatment-naive patients with JIA [polyarticular JIA, n = 22, oligoarticular JIA, n = 31, and spondyloarthropathies (SpA), n = 16], patients with established inflammatory bowel disease-related arthritis (IBD-RA, n = 11), and 34 healthy controls. We determined circulating IgG reactivity against LPS, LPS-binding protein (LBP), α-1-acid glycoprotein (α-1AGP), and C-reactive protein (CRP) in plasma or serum from these patients and controls. Juvenile Arthritis Disease Activity Score (JADAS-27) was calculated for patients with JIA.
resultsCirculating anticore LPS antibody concentrations in patients with polyarticular JIA (p = 0.001), oligoarticular JIA (p = 0.024), and SpA (p = 0.001) were significantly greater than in controls, but there were no significant intergroup differences. Circulating LBP concentrations were also significantly greater in patients with polyarticular JIA (p = 0.001), oligoarticular JIA (p = 0.002), and SpA (p = 0.006) than controls, as were α-1AGP concentrations (p = 0.001, 0.001, and 0.003, respectively). No differences were observed between controls and patients with IBD-RA in any of the assays. Circulating concentrations of LBP and α-1AGP correlated strongly with CRP concentrations (r = 0.78 and r = 0.66, respectively). Anticore LPS antibody levels and CRP (r = 0.26), LBP (r = 0.24), and α-AGP (r = 0.22) concentrations had weaker correlations. JADAS-27 scores correlated with LBP (r = 0.66) and α-1AGP concentrations (r = 0.58).
conclusionChildren with polyarticular JIA, oligoarticular JIA, and SpA have evidence of increased exposure to gut bacterial products. These data reinforce the concept that the intestine is a source of immune stimulation in JIA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.