ArticleMolecular systems biology2017
A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance.
Article in Molecular systems biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Remembrance of things past: Towards a life-course biology of aging.PLoS biology · 2026Article
- ß-adrenergic-like signalling engages CrebB in Drosophila gut to promote female longevity.Nature communications · 2026Article
- Adipose Dicer-1 modulates systemic insulin signaling and longevity via a miR-8-Aop-Dilp6 axis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Xbp1 targets canonical UPRiScience · 2024Article
- KDM5-mediated activation of genes required for mitochondrial biology is necessary for viability in Drosophila.Development (Cambridge, England) · 2023Article
- Repeat length of C9orf72-associated glycine-alanine polypeptides affects their toxicity.Acta neuropathologica communications · 2023Article
- Reduced insulin signaling in neurons induces sex-specific health benefits.Science advances · 2023Article
- Molecular inhibition of RAS signalling to target ageing and age-related health.Disease models & mechanisms · 2022Review
- Inherent constraints on a polyfunctional tissue lead to a reproduction-immunity tradeoff.BMC biology · 2022Article
- Article
- Tissue-specific modulation of gene expression in response to lowered insulin signalling ineLife · 2021Article
- Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- FoxO1 Is a Novel Regulator of 20S Proteasome Subunits Expression and Activity.Frontiers in cell and developmental biology · 2021Article
- Recent advances in understanding the role of proteostasis.Faculty reviews · 2021Review
- Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila.Scientific reports · 2020Article
- Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling.BMC biology · 2020Article
- An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila.Molecular cell · 2020Article
- Ageing, metabolism and the intestine.EMBO reports · 2020Review
- Increased mitochondrial and lipid metabolism is a conserved effect of Insulin/PI3K pathway downregulation in adipose tissue.Scientific reports · 2020Article
- Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production.Aging cell · 2020Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
Lowered activity of the insulin/IGF signalling (IIS) network can ameliorate the effects of ageing in laboratory animals and, possibly, humans. Although transcriptome remodelling in long-lived IIS mutants has been extensively documented, the causal mechanisms contributing to extended lifespan, particularly in specific tissues, remain unclear. We have characterized the proteomes of four key insulin-sensitive tissues in a long-lived
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.