SynthesisNeurology2017
Sex differences in the prevalence of genetic mutations in FTD and ALS: A meta-analysis.
Open access · greenAbstract readMeta-AnalysisReview
In one paragraph
Synthesis in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- The differences in sex ratio between sporadic and familial amyotrophic lateral sclerosis: a systematic review.Journal of neurology · 2026Pooled it
- NAT10 inhibition corrects nuclear defects in tau mutant human neurons and extends lifespan in aiScience · 2026Article
- Sex-Specific Genetic Architecture of ALS: Evidence of a Female Protective Effect?Annals of neurology · 2026Article
- Feasibility of identifying factors related to Alzheimer's disease and related dementia in real-world data.JAMIA open · 2026Review
- Pathogenic or Likely Pathogenic GRN Variants Are Found in 0.1% of Parkinson's Disease Patients.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Traumatic Brain Injury and Axonal Damage in the Pathogenesis of Frontotemporal Dementia: A Narrative Review.Cureus · 2026Review
- Article
- Predictive Analysis of Amyotrophic Lateral Sclerosis Progression and Mortality in a Clinic Cohort From Singapore.Muscle & nerve · 2025Article
- Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells.Translational neurodegeneration · 2025Review
- Machine learning identified novel players in lipid metabolism, endosomal trafficking, and iron metabolism of the ALS spinal cord.Scientific reports · 2025Article
- Effects of sex, mating status, and genetic background on circadian behavior inbioRxiv : the preprint server for biology · 2024Article
- Brain-body mechanisms contribute to sexual dimorphism in amyotrophic lateral sclerosis.Nature reviews. Neurology · 2024Review
- MAPT Mutations V337M and N297K Alter Organelle Trafficking in Frontotemporal Dementia Patient-Specific Motor Neurons.Biomedicines · 2024Article
- Perinatal Tissue-Derived Stem Cells: An Emerging Therapeutic Strategy for Challenging Neurodegenerative Diseases.International journal of molecular sciences · 2024Review
- Effects of sex, mating status, and genetic background on circadian behavior inFrontiers in neuroscience · 2024Article
- Evaluation of an educational conference for persons affected by hereditary frontotemporal degeneration and amyotrophic lateral sclerosis.PEC innovation · 2023Article
- Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease.Journal of neuroinflammation · 2023Review
- TDP-43 Epigenetic Facets and Their Neurodegenerative Implications.International journal of molecular sciences · 2023Review
- Sex and gender considerations in dementia: a call for global research.Nature aging · 2023Article
- Neuroprotection by upregulation of the major histocompatibility complex class I (MHC I) in SOD1Frontiers in cellular neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Ashley F CurtisFrom the Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (A.F.C., M.M., K.Z., M.C.T.), Primary Care Research Unit (A.F.C., K.Z., B.A., G.M., M.C.T.), and Cognitive & Movement Disorders Clinic (M.M.), Sunnybrook Health Sciences Center, Toronto; Division of Neurology (G.-Y.R.H.) and Department of Pathology and Laboratory Medicine (I.M.), University of British Columbia, Vancouver; Departments of Family and Community Medicine (R.M., M.C.T.) and Medicine (E.R.) and Tanz Centre for Research in Neurodegenerative Diseases (E.R.), University of Toronto; and Department of Neuropathology (I.M.), Vancouver General Hospital, Canada.
Mario MasellisFrom the Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (A.F.C., M.M., K.Z., M.C.T.), Primary Care Research Unit (A.F.C., K.Z., B.A., G.M., M.C.T.), and Cognitive & Movement Disorders Clinic (M.M.), Sunnybrook Health Sciences Center, Toronto; Division of Neurology (G.-Y.R.H.) and Department of Pathology and Laboratory Medicine (I.M.), University of British Columbia, Vancouver; Departments of Family and Community Medicine (R.M., M.C.T.) and Medicine (E.R.) and Tanz Centre for Research in Neurodegenerative Diseases (E.R.), University of Toronto; and Department of Neuropathology (I.M.), Vancouver General Hospital, Canada.
Ging-Yuek Robin HsiungFrom the Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (A.F.C., M.M., K.Z., M.C.T.), Primary Care Research Unit (A.F.C., K.Z., B.A., G.M., M.C.T.), and Cognitive & Movement Disorders Clinic (M.M.), Sunnybrook Health Sciences Center, Toronto; Division of Neurology (G.-Y.R.H.) and Department of Pathology and Laboratory Medicine (I.M.), University of British Columbia, Vancouver; Departments of Family and Community Medicine (R.M., M.C.T.) and Medicine (E.R.) and Tanz Centre for Research in Neurodegenerative Diseases (E.R.), University of Toronto; and Department of Neuropathology (I.M.), Vancouver General Hospital, Canada.
Rahim MoineddinFrom the Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (A.F.C., M.M., K.Z., M.C.T.), Primary Care Research Unit (A.F.C., K.Z., B.A., G.M., M.C.T.), and Cognitive & Movement Disorders Clinic (M.M.), Sunnybrook Health Sciences Center, Toronto; Division of Neurology (G.-Y.R.H.) and Department of Pathology and Laboratory Medicine (I.M.), University of British Columbia, Vancouver; Departments of Family and Community Medicine (R.M., M.C.T.) and Medicine (E.R.) and Tanz Centre for Research in Neurodegenerative Diseases (E.R.), University of Toronto; and Department of Neuropathology (I.M.), Vancouver General Hospital, Canada.
Kathy ZhangFrom the Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (A.F.C., M.M., K.Z., M.C.T.), Primary Care Research Unit (A.F.C., K.Z., B.A., G.M., M.C.T.), and Cognitive & Movement Disorders Clinic (M.M.), Sunnybrook Health Sciences Center, Toronto; Division of Neurology (G.-Y.R.H.) and Department of Pathology and Laboratory Medicine (I.M.), University of British Columbia, Vancouver; Departments of Family and Community Medicine (R.M., M.C.T.) and Medicine (E.R.) and Tanz Centre for Research in Neurodegenerative Diseases (E.R.), University of Toronto; and Department of Neuropathology (I.M.), Vancouver General Hospital, Canada.
Bonnie AuFrom the Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (A.F.C., M.M., K.Z., M.C.T.), Primary Care Research Unit (A.F.C., K.Z., B.A., G.M., M.C.T.), and Cognitive & Movement Disorders Clinic (M.M.), Sunnybrook Health Sciences Center, Toronto; Division of Neurology (G.-Y.R.H.) and Department of Pathology and Laboratory Medicine (I.M.), University of British Columbia, Vancouver; Departments of Family and Community Medicine (R.M., M.C.T.) and Medicine (E.R.) and Tanz Centre for Research in Neurodegenerative Diseases (E.R.), University of Toronto; and Department of Neuropathology (I.M.), Vancouver General Hospital, Canada.
Geneva MillettFrom the Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (A.F.C., M.M., K.Z., M.C.T.), Primary Care Research Unit (A.F.C., K.Z., B.A., G.M., M.C.T.), and Cognitive & Movement Disorders Clinic (M.M.), Sunnybrook Health Sciences Center, Toronto; Division of Neurology (G.-Y.R.H.) and Department of Pathology and Laboratory Medicine (I.M.), University of British Columbia, Vancouver; Departments of Family and Community Medicine (R.M., M.C.T.) and Medicine (E.R.) and Tanz Centre for Research in Neurodegenerative Diseases (E.R.), University of Toronto; and Department of Neuropathology (I.M.), Vancouver General Hospital, Canada.
Ian MackenzieFrom the Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (A.F.C., M.M., K.Z., M.C.T.), Primary Care Research Unit (A.F.C., K.Z., B.A., G.M., M.C.T.), and Cognitive & Movement Disorders Clinic (M.M.), Sunnybrook Health Sciences Center, Toronto; Division of Neurology (G.-Y.R.H.) and Department of Pathology and Laboratory Medicine (I.M.), University of British Columbia, Vancouver; Departments of Family and Community Medicine (R.M., M.C.T.) and Medicine (E.R.) and Tanz Centre for Research in Neurodegenerative Diseases (E.R.), University of Toronto; and Department of Neuropathology (I.M.), Vancouver General Hospital, Canada.
Ekaterina RogaevaFrom the Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (A.F.C., M.M., K.Z., M.C.T.), Primary Care Research Unit (A.F.C., K.Z., B.A., G.M., M.C.T.), and Cognitive & Movement Disorders Clinic (M.M.), Sunnybrook Health Sciences Center, Toronto; Division of Neurology (G.-Y.R.H.) and Department of Pathology and Laboratory Medicine (I.M.), University of British Columbia, Vancouver; Departments of Family and Community Medicine (R.M., M.C.T.) and Medicine (E.R.) and Tanz Centre for Research in Neurodegenerative Diseases (E.R.), University of Toronto; and Department of Neuropathology (I.M.), Vancouver General Hospital, Canada.
Mary C TierneyFrom the Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (A.F.C., M.M., K.Z., M.C.T.), Primary Care Research Unit (A.F.C., K.Z., B.A., G.M., M.C.T.), and Cognitive & Movement Disorders Clinic (M.M.), Sunnybrook Health Sciences Center, Toronto; Division of Neurology (G.-Y.R.H.) and Department of Pathology and Laboratory Medicine (I.M.), University of British Columbia, Vancouver; Departments of Family and Community Medicine (R.M., M.C.T.) and Medicine (E.R.) and Tanz Centre for Research in Neurodegenerative Diseases (E.R.), University of Toronto; and Department of Neuropathology (I.M.), Vancouver General Hospital, Canada. mary.tierney@sunnybrook.ca.
University of British Columbia · CAUniversity of Toronto · CA
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo conduct a meta-analysis that investigates sex differences in the prevalence of mutations in the 3 most common genes that cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)-chromosome 9 open reading frame 72 (
methodsMEDLINE, EMBASE, and PsycINFO databases were searched (inception to June 30, 2016). Studies of patients with FTD or ALS that reported the number of men and women with and without mutations of interest were selected. Female to male pooled risk ratios (RR) and 95% confidence intervals (CI) for each mutation were calculated using random-effects models.
resultsThirty-two articles reporting 12,784 patients with ALS (including 1,244
conclusionsHigher female prevalence of
Indexed as
Amyotrophic Lateral SclerosisC9orf72 ProteinDatabases, BibliographicFemaleFrontotemporal DementiaHumansIntercellular Signaling Peptides and ProteinsMaleMicrotubule-Associated ProteinsMutationProgranulinsProteinsSex FactorsC9orf72 ProteinC9orf72 protein, humanGRN protein, humanIntercellular Signaling Peptides and ProteinsMicrotubule-Associated ProteinsProgranulinsProteins
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.