Evidence map›Paper›PMID 28916531›Full record

ArticleDiabetes care2017

Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS).

Andrea L C Schneider, Elizabeth Selvin, A Richey Sharrett, Michael Griswold, Josef Coresh, Clifford R Jack, David Knopman, Thomas Mosley, Rebecca F Gottesman

Abstract read
In one paragraph

Article in Diabetes care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 3 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 3 syntheses or guidelines pooled it, 109 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Disentangling treatment status from disease severity in studies of diabetes and Alzheimer's disease biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  7. Article
  8. Association of type 2 diabetes treatment status with in vivo biomarkers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  9. Article
  10. Regional Brain Structure Alterations in Diabetes but Not Prediabetes.The Journal of clinical endocrinology and metabolism · 2025
    Article
  11. Article
  12. Article
  13. Lower slow wave sleep and rapid eye movement sleep are associated with brain atrophy of Alzheimer's disease-vulnerable regions.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. A comparison of PMEnvironmental research · 2024
    Article
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Andrea L C SchneiderDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD achris13@jhmi.edu.ORCID 0000-0003-0026-5052
Elizabeth SelvinDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.ORCID 0000-0001-6923-7151
A Richey SharrettDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Michael GriswoldCenter of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS.
Josef CoreshDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, MN.
David KnopmanDepartment of Neurology, Mayo Clinic, Rochester, MN.
Thomas MosleyDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS.
Rebecca F GottesmanDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Johns Hopkins University · USMayo Clinic in Arizona · USUniversity of Mississippi Medical Center · US

Funding

ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
ARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5M
ARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 4 of 5U01HL096814 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M., WAGENKNECHT, LYNNE E · 2010 to 2018
$6.5M
Diabetes and Prediabetes in Older Adults in ARICR01DK089174 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SELVIN, ELIZABETH · 2011 to 2020
$6.4M
Research Education Program for Residents and Fellows in Neurology - PorrasR25NS065729 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HILLIS, ARGYE E. · 2009 to 2024
$3.3M
Neuroepidemiology of the vascular contribution to cognitive impairment and Alzheimer's diseaseK24AG052573 · NIA · JOHNS HOPKINS UNIVERSITY · PI GOTTESMAN, REBECCA F · 2016 to 2020
$803k
Research and Mentoring in the Clinical Epidemiology of Type 2 DiabetesK24DK106414 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SELVIN, ELIZABETH · 2015 to 2019
$654k
NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NIA NIH HHS K24 AG052573NIDDK NIH HHS K24 DK106414NIDDK NIH HHS R01 DK089174NINDS NIH HHS R25 NS065729
6 · The paper itself

Abstract

objectiveTo examine the associations of prediabetes, diabetes, and diabetes severity (as assessed by HbA RESEARCH DESIGN AND

methodsCross-sectional study of 1,713 participants in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS) (mean age 75 years, 60% female, 27% black, 30% prediabetes, and 35% diabetes) who underwent 3T brain MRI scans in 2011-2013. Participants were categorized by diabetes-HbA

resultsIn adjusted analyses, compared with participants without diabetes and HbA

conclusionsMore-severe diabetes (defined by higher HbA

Indexed as

AtherosclerosisBiomarkersBrainCerebrovascular DisordersCross-Sectional StudiesDiabetes MellitusFemaleFollow-Up StudiesGlycated HemoglobinHumansMagnetic Resonance ImagingMaleMiddle AgedNeurocognitive DisordersOrgan SizePrediabetic StateBiomarkersGlycated Hemoglobin

Identifiers

PMID28916531
PMCPMC5652590
OpenAlexW2754391392

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.