Evidence map›Paper›PMID 28916515›Full record

ArticleJournal of cell science2017

Reversing thyroid-hormone-mediated repression of a HSV-1 promoter via computationally guided mutagenesis.

Robert W Figliozzi, Feng Chen, Shaochung V Hsia

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Robert W FigliozziDepartment of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland Eastern Shore, Princess Anne, MD 21853, USA.
Feng ChenDepartment of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland Eastern Shore, Princess Anne, MD 21853, USA.
Shaochung V HsiaDepartment of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland Eastern Shore, Princess Anne, MD 21853, USA vhsia@umes.edu.ORCID http://orcid.org/0000-0001-7623-2842
University of Maryland Eastern Shore · US

Funding

REGULATION OF HSV-1 GENE EXPRESSION AND REPLICATION BY NUCLEAR HORMONE RECEPTORS-Research SupplementR01NS081109 · NINDS · UNIVERSITY OF MARYLAND EASTERN SHORE · PI HSIA, SHAOCHUNG VICTOR · 2012 to 2016
$794k
NINDS NIH HHS R01 NS081109
6 · The paper itself

Abstract

Thyroid hormones (THs) and their DNA-binding nuclear receptors (TRs) direct transcriptional regulation in diverse ways depending on the host cell environment and specific promoter characteristics of TH-sensitive genes. This study sought to elucidate the impact on transcriptional repression of nucleotide sequence or orientation within TR binding sites - the TH response elements (TREs) of TH-sensitive promoters - to better understand ligand-dependent transcriptional repression of wild-type promoters. Computational analysis of the HSV-1 thymidine kinase (TK) gene TRE bound by TR and retinoid X receptor (RXR) revealed a single TRE point mutation sufficient to reverse the TRE orientation.

Indexed as

Promoter Regions, GeneticBase SequenceBinding SitesCell DifferentiationCell Line, TumorChromatinGene Expression RegulationHerpesvirus 1, HumanHistonesHumansMaleMutagenesis, Site-DirectedPoint MutationProstateProtein BindingReceptors, Thyroid HormoneChromatinHistonesReceptors, Thyroid HormoneRetinoid X ReceptorsThymidine KinaseThyroid HormonesDifferentiationHerpesvirusHistone modificationThyroid hormoneTranscription factor

Identifiers

PMID28916515
PMCPMC5702054
OpenAlexW2756294552

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.