Trial reportJournal of cardiac failure2018
Dietary Nitrate Increases VO
4 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Journal of cardiac failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
10.6field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dietary Nitrate and Muscle Power With Aging
Dose-response Effect of Dietary Nitrate on Muscle Function in Older Individuals
Acute Effects of Beetroot Juice on Locomotor Economy and Capacity in Chronic Stroke
The Influence of Active Muscle Mass and Nitrate Supplementation on Fatigability in Individuals With Heart Failure
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Systematic review and meta-analysis of nitrates/nitrites in patients with heart failure or pulmonary hypertension.European journal of medical research · 2025Pooled it
- Ergogenic Effect of Nitrate Supplementation in Clinical Populations: A Systematic Review and Meta-Analysis.Nutrients · 2024Pooled it
- Effects of dietary nitrate supplementation on peak oxygen uptake following 10 days of Ramadan fasting in healthy adults.Experimental physiology · 2026Trial
- Acute effects of beetroot extract and resveratrol ingestion on cardiovascular and cardiac autonomic modulation recovery after moderate-intensity aerobic exercise in individuals with coronary artery disease: a triple-blinded, randomized, placebo-controlled trial.European journal of nutrition · 2025Trial
- Inorganic nitrate supplementation and blood flow restricted exercise tolerance in post-menopausal women.Nitric oxide : biology and chemistry · 2022Trial
- Dose-Response Effect of Dietary Nitrate on Muscle Contractility and Blood Pressure in Older Subjects: A Pilot Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Trial
- The Relationship between Resistance Exercise Performance and Ventilatory Efficiency after Beetroot Juice Intake in Well-Trained Athletes.Nutrients · 2021Trial
- A randomized controlled trial of nitrate supplementation in well-trained middle and older-aged adults.PloS one · 2020Trial
- Acute interaction between oral glucose (75 g as Lucozade) and inorganic nitrate: Decreased insulin clearance, but lack of blood pressure-lowering.British journal of clinical pharmacology · 2019Trial
- Influence of exercise training on nitric oxide pathways and their physiological effects.Redox biology · 2026Review
- Dietary Nitrate Prevents Cardiac Dysfunction in HFrEF by Improving Hemodynamics, Ameliorating Remodeling, and Resolving Inflammation.Acta physiologica (Oxford, England) · 2025Article
- Oral nitrate-reducing capacity and aerobic fitness are impaired in older individuals with heart failure with reduced ejection fraction.American journal of physiology. Heart and circulatory physiology · 2025Article
- Effect of pre-exercise dietary nitrate on skeletal muscle blood flow in a rat model of pulmonary hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- The inorganic NItrate and eXercise performance in Heart Failure (iNIX-HF) phase II clinical trial: Rationale and study design.Contemporary clinical trials communications · 2023Article
- Effects of Dietary Nitrate Supplementation on Performance during Single and Repeated Bouts of Short-Duration High-Intensity Exercise: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.Antioxidants (Basel, Switzerland) · 2023Review
- Skeletal Muscle Contractile Function in Heart Failure With Reduced Ejection Fraction-A Focus on Nitric Oxide.Frontiers in physiology · 2022Review
- Severe loss of mechanical efficiency in COVID-19 patients.Journal of cachexia, sarcopenia and muscle · 2021Article
- Effects of inorganic nitrate supplementation on cardiovascular function and exercise tolerance in heart failure.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Review
- Nutraceutical, Dietary, and Lifestyle Options for Prevention and Treatment of Ventricular Hypertrophy and Heart Failure.International journal of molecular sciences · 2021Review
- Acute beetroot juice supplementation improves exercise tolerance and cycling efficiency in adults with obesity.Physiological reports · 2020Article
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
12 authors at 2 institutions in 1 country.
Andrew R CogganDepartment of Kinesiology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana; Department of Cellular and Integrative Physiology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana; Department of Radiology, Washington University School of Medicine, St. Louis, Missouri. Electronic address: acoggan@iupui.edu.
Seth R BroadstreetDepartment of Kinesiology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana.
Kiran MahmoodDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Deana MikhalkovaDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Michael MadiganDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Indra BoleDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Soo ParkDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Joshua L LeibowitzDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Ana KadkhodayanDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Deepak P ThomasDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Dakkota ThiesDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Linda R PetersonDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Washington University in St. Louis · USIndiana University – Purdue University Indianapolis · US
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MNCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NIDDK NIH HHS P30 DK056341
Abstract
backgroundPatients with heart failure with reduced ejection fraction (HFrEF) exhibit lower efficiency, dyspnea, and diminished peak oxygen uptake (VO METHODS AND
resultsPlasma NO
conclusionsAcute dietary NO
Indexed as
Dietary SupplementsCross-Over StudiesDouble-Blind MethodExercise ToleranceFemaleFollow-Up StudiesHeart FailureHumansMaleMiddle AgedNitritesOxygenOxygen ConsumptionRespirationStroke VolumeNitritesOxygenexerciseheart failureNitric oxideVO(2)peak
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT03513302ClinicalTrials.gov
NCT03595774ClinicalTrials.gov
NCT05720013ClinicalTrials.gov
NCT06551012ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.